中国临床药理学与治疗学2026，Vol.31Issue(5)：639-648,10.DOI:10.12092/j.issn.1009-2501.2026.05.008
放射性心脏病体外模型的构建策略与应用挑战
Construction strategy and application of an in vitro model of radioac-tive cardiac injury
摘要
Abstract
Radiation-induced heart disease is the most common and severe complication of radiation therapy for thoracic tumours.After exposure to ra-diation,cardiac tissue undergoes myocardial inflam-mation,fibrosis,and vascular endothelial damage,leading to cardiac dysfunction.With the continuous improvement of medical technology,the survival period of tumour patients has been significantly ex-tended.However,RIHD severely impacts patients'quality of life.To thoroughly investigate its patho-logical mechanisms,establishing a reliable RIHD cell model is a crucial experimental foundation for studying its molecular mechanisms and evaluating treatment efficacy.This article reviews and sum-marises the application and research progress of RI-HD cell models in related studies both domestically and internationally in recent years,aiming to pro-vide a reliable theoretical basis for RIHD research.关键词
放射性心脏病/细胞模型/标准化/药物筛选Key words
radiation-induced/cellular model/standardization/drug screening分类
医药卫生引用本文复制引用
王夏颖,蒋虎刚,任春贞,马静,刘佳坤,刘凯,李应东,赵信科..放射性心脏病体外模型的构建策略与应用挑战[J].中国临床药理学与治疗学,2026,31(5):639-648,10.基金项目
国家自然科学基金资助项目(82360926) （82360926）
中医药传承与创新"百千万"人才工程(岐黄工程)青年岐黄学者基金资助项目 （岐黄工程）
国家中医药管理局"李应东全国名中医传承工作室"建设项目(国中医药办人教函[2022]5号) （国中医药办人教函[2022]5号）
甘肃省科技重大专项计划(20ZD7FA002) （20ZD7FA002）
"双一流"科研重点项目(GSSYLXM-05) （GSSYLXM-05）
甘肃省中医药科研课题项目(GZKZD-2018-02,GZKP-2023-59) （GZKZD-2018-02,GZKP-2023-59）
甘肃中医药大学第三附属医院院内课题(2022YK-11) （2022YK-11）
甘肃省教育厅:优秀研究生"创新之星"项目(2025CXZX-939) （2025CXZX-939）
甘肃中医药大学研究生创新基金资助项目(2025CXCY-007) （2025CXCY-007）
