中国临床药理学与治疗学2026，Vol.31Issue(5)：658-665,8.DOI:10.12092/j.issn.1009-2501.2026.05.010
心脏淋巴管生成在心血管疾病中的最新研究进展
Recent advances of cardiac lymphangiogenesis in cardiovascular dis-ease
摘要
Abstract
Cardiac lymphatics play a major role in the maintenance of tissue-fluid homeostasis,im-mune response,and lipid uptake.However,im-paired/excessive cardiac lymphatic remodeling and inadequate lymphatic drainage are associated with the development of several cardiovascular diseases(CVDs).This review systematically summarizes the molecular mechanisms of cardiac lymphangiogene-sis and elucidates their dynamic role in CVDs.Mean-while,this article also explores the role of lymphat-ic-immune interactions in the repair process of my-ocardial tissue injury and the potential value of tar-geted lymphangiogenesis in the treatment of CVDs.Early stages of lymphangiogenesis may promote re-pair by removing metabolic waste and reducing edema,whereas hyperactivation or dysfunction in the chronic phase may exacerbate fibrosis and the spread of inflammation.Therefore,an in-depth study of the cardiac lymphangiogenesis in CVDs will provide an important theoretical basis for the de-velopment of new therapeutic strategies.关键词
淋巴管生成/心血管疾病/调节因子/淋巴-免疫/治疗策略Key words
lymphangiogenesis/cardiovascular diseases/regulatory factors/lymphatic-immune/therapeutic strategies分类
医药卫生引用本文复制引用
杨雅坤,樊官伟,李澜..心脏淋巴管生成在心血管疾病中的最新研究进展[J].中国临床药理学与治疗学,2026,31(5):658-665,8.基金项目
天津市自然科学基金青年项目(23JCQNJC01070) （23JCQNJC01070）
