中国临床医学影像杂志2026，Vol.37Issue(5)：323-327,5.DOI:10.12117/jccmi.2026.05.005
基于18F-FDG PET/CT代谢参数、临床特征分析非小细胞肺癌纵隔淋巴结转移的影响因素
Analysis of the influencing factors of mediastinal lymph node metastasis in non-small cell lung cancer based on 18F-FDG PET/CT metabolic parameters and clinical characteristics
摘要
Abstract
Objective:To analyze the influencing factors of mediastinal lymph node metastasis(MLNM)in non-small cell lung cancer(NSCLC).Methods:NSCLC patients who received treatment at the Affiliated Hospital of Xuzhou Medical University were included in the study from January 2023 to January 2025.The clinical data of 248 patients were retrospectively ana-lyzed.They were divided into the MLNM group(73 cases)and the non MLNM group(175 cases)based on whether they had MLNM.This study adopted a control analysis method.Firstly,the differences of the baseline data and metabolic parameters of 18F-FDG PET/CT imaging between the two groups were compared.Then,a multivariate Logistic regression model was used to screen independent risk factors and establish the corresponding regression equation.Finally,the diagnostic efficacy of the re-gression equation was evaluated through the ROC curve,and the area under the curve(AUC)was calculated to verify its pre-dictive accuracy.Results:Central type tumors,tumor solid proportion≥80%,large primary lesion diameter,high tumor metabolic volume(MTV),high primary lesion maximum standardized uptake value(SUVmax),high lesion total glycolysis(TLG),high ratio of SUVmax of the primary lesion to the mediastinal blood pool SUVmean(SURblood),and high ratio of SUVmax of the primary le-sion to the liver SUVmean(SURliver)were independent risk factors for NSCLC with MLNM(P<0.05).Construct regression equation:logit(P)=-7.432+tumor classification×0.879+solid proportion of chest tumor×1.032+maximum diameter of primary lesion×0.657+MTV×0.980+SUVmax of primary lesion×1.114+TLG of lesion×0.879+SURblood×0.987+SURliver×0.687.The ROC curve showed that when logit(P)>0.21,the AUC value and χ2 were 0.876 and 17.257,respectively,the diagnostic sensitivity and specificity were 87.67%and 74.86%,respectively.Conclusion:The independent risk factors of NSCLC with MLNM included central type tu-mors,tumor solid proportion≥80%,large primary lesion diameter,high MTV,high primary lesion SUVmax,high lesion TLG,high SURblood,and high SURliver.The regression equation constructed based on this had high predictive value.关键词
癌,非小细胞肺/肿瘤转移/纵隔肿瘤/正电子发射断层显像计算机体层摄影术Key words
Carcinoma,Non-Small-Cell Lung/Neoplasm Metastasis/Mediastinal Neoplasms/Positron Emission Tomography Computed Tomography分类
医药卫生引用本文复制引用
吴仪仪,庞建鑫,王伟..基于18F-FDG PET/CT代谢参数、临床特征分析非小细胞肺癌纵隔淋巴结转移的影响因素[J].中国临床医学影像杂志,2026,37(5):323-327,5.基金项目
徐州市科技项目(KC23328). （KC23328）
