中国美容医学2026，Vol.35Issue(6)：26-30,5.
烧伤患者血清细胞因子及淋巴细胞水平变化与烧伤程度和创面愈合的关系研究
Study on the Relationship between the Changes of Serum Cytokines and Lymphocytes in Burn Patients and the Degree of Burn and Wound Healing
摘要
Abstract
Objective To study the relationship between the changes of serum cytokines and lymphocytes in burn patients and the degree of burn and wound healing.Methods 98 burn patients admitted to the General Hospital of Taiyuan Iron and Steel(Group)Co.,Ltd.from May 2023 to January 2025 were selected as the burn group,and the clinical data of 98 healthy burn scar patients admitted to the hospital during the same period were selected as the control group.The wound healing rate of burn patients after 2 weeks of treatment was counted.The levels of serum cytokines and peripheral blood lymphocytes were compared between the two groups,and the levels of serum cytokines and peripheral blood lymphocytes before and after treatment for 2 weeks in patients with different degrees of burn were compared.The correlation between serum cytokines,peripheral blood lymphocyte levels and wound healing in burn patients was analyzed.Results The wound healing rate of the burn group was(79.84±5.63)%after 2 weeks of treatment.The levels of Silent Mating Type Information Regulation 2 Homolog 1(SIRT1),Erythropoietin(EPO),Soluble Intercellular Adhesion Molecule-1(sICAM-1)and peripheral blood CD8+in the burn group were higher than those in the control group,while the levels of peripheral blood CD8+and CD4+/CD8+were lower than those in the control group(P＜0.05).Before treatment and after 2 weeks of treatment,the levels of serum SIRT1,EPO,sICAM-1 and peripheral blood CD8+in shallow II degree group,deep II degree group and III degree group showed an increasing trend,while the levels of peripheral blood CD4+and CD4+/CD8+showed a decreasing trend(P＜0.05).After 2 weeks of treatment,the levels of serum SIRT1,EPO,sICAM-1 and peripheral blood CD8+in the superficial II degree group,deep II degree group and III degree group were lower than those before treatment,and the levels of peripheral blood CD4+and CD4+/CD8+were higher than those before treatment(P＜0.05).Serum SIRT1,EPO,peripheral blood CD4+level and CD4+/CD8+were positively correlated with wound healing rate(r=0.637,0.718,0.627,0.619,P＜0.05).Serum levels of sICAM-1 and peripheral blood CD8+were negatively correlated with wound healing rate(r=-0.584,-0.498,P＜0.05).Conclusion The levels of serum SIRT1,EPO,sICAM-1 and peripheral blood lymphocytes in patients with burns and different degrees of burns are significantly different,and their levels were closely related to the wound healing of patients.关键词
烧伤/细胞因子/淋巴细胞/创面愈合Key words
burn/cytokines/lymphocyte/wound healing分类
医药卫生引用本文复制引用
胡冰,郭万里,段鹏,成剑..烧伤患者血清细胞因子及淋巴细胞水平变化与烧伤程度和创面愈合的关系研究[J].中国美容医学,2026,35(6):26-30,5.基金项目
2024年度山西省高等学校科技创新项目(编号:2024L116) （编号:2024L116）
