中国比较医学杂志2026，Vol.36Issue(8)：20-30,11.DOI:10.3969/j.issn.1671-7856.2026.08.003
长期食用转cry1Ab/cry2Aj和G10evo-epsps基因抗虫耐除草剂玉米对食蟹猴两代骨密度的影响
Effects of long-term consumption of insect-resistant and herbicide-tolerant maize with cry1Ab/cry2Aj and G10evo-epsps on bone density in two generations of Macaca fascicularis
摘要
Abstract
Objective To assess the effects of long-term feeding of transgenic cry1Ab/cry2Aj and G10evo-epsps insect-resistant and herbicide-tolerant maize on bone mineral content(BMC)and density(BMD)in two generations of Macaca fascicularis.Methods A total of 24 parental(F0)cynomolgus monkeys were divided into 70％genetically modified corn(GM;n=8),70％non-genetically modified corn(Non-GM;n=7),and normal feed control groups(Normal;n=9).The offspring(F1)generation included 46 Macaca fascicularis,comprising 16 in the GM group,13 in the Non-GM group,and 17 in the Normal group,with age ranges spanning 1～6 years.Lunar densitometers were used to scan and analyze BMC and BMD in the head,arms,legs,pelvis,spine,and whole body of animals in each group.Results No significant BMC and BMD differences(P＞0.05)were observed between groups in the head,arms,legs,pelvis,spine,or whole body at three age stages(1～2,3～4,and 5～6 years)in both F0 and F1 generations.Conclusions Long-term feeding with insect-resistant and herbicide-tolerant transgenic maize did not significantly affect BMC and BMD in either parental or offspring generations of Macaca fascicularis.This study provides reference data for evaluating the long-term safety of consuming this genetically modified maize.关键词
食蟹猴/转基因玉米/cry1Ab/cry2Aj/G10evo-epsps/骨矿含量/骨密度Key words
Macaca fascicularis/genetically modified maize/cry1Ab/cry2Aj/G10evo-epsps/bone mineral content/bone mineral density分类
医药卫生引用本文复制引用
李哲丽,伍付金,范梅花,李咏洁,唐东红,王陈芸,龙维虎,施红进,李明昊,杨彪,施红丽,吕秋林,矣佳鑫..长期食用转cry1Ab/cry2Aj和G10evo-epsps基因抗虫耐除草剂玉米对食蟹猴两代骨密度的影响[J].中国比较医学杂志,2026,36(8):20-30,11.基金项目
农业生物育种国家科技重大专项(2023ZD0406306) （2023ZD0406306）
中国医学科学院医学与健康科技创新工程重大协同创新项目(2021-I2M-024). （2021-I2M-024）
