中国比较医学杂志2026，Vol.36Issue(8)：82-96,15.DOI:10.3969/j.issn.1671-7856.2026.08.008
早发性卵巢功能不全相关信号通路及其中医药调控研究进展
Progress on signaling pathways related to early-onset ovarian insufficiency and traditional Chinese medicine regulation
摘要
Abstract
Premature ovarian insufficiency(POI)is a condition that severely impacts female physical and mental health;it is a primary cause of female infertility,with its incidence rate continuously rising in recent years.Although hormone replacement therapy has achieved good efficacy in clinical practice,its long-term use can lead to many adverse reactions.Finding safe and effective POI treatments has become an urgent issue.Traditional Chinese medicine can regulate phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),Wnt family secreted glycoprotein/β-catenin(Wnt/β-catenin),transforming growth factor-β(TGF-β)/Smads,and nuclear factor erythroid 2-related factor(Nrf2)signaling,along with other related signaling pathways.It can also inhibit follicular granulosa cell apoptosis,reduce inflammatory responses and oxidative stress damage,regulate hormone levels,improve ovarian function,and delay ovarian aging.Traditional Chinese medicine presents advantages in POI treatment,with significant clinical effects and high safety.Through exploring research into the signaling pathways in POI,this paper reviews and analyzes literature on the active components of traditional Chinese medicine and their use in POI treatment by modulating related signaling pathways,aiming to offer guidance for future research.关键词
卵巢早衰/信号通路/研究进展/中医药/作用机制Key words
premature ovarian failure/signaling pathway/research progress/traditional Chinese medicine/mechanism of action分类
医药卫生引用本文复制引用
刘晨,马丽亚,张雪琳,张大伟..早发性卵巢功能不全相关信号通路及其中医药调控研究进展[J].中国比较医学杂志,2026,36(8):82-96,15.基金项目
国家自然科学基金面上项目(82074562) （82074562）
河南省自然科学基金面上项目(242300420168) （242300420168）
河南省卫生健康委员会中医药科学研究专项课题重大课题(2023ZYZD09) （2023ZYZD09）
河南省科学技术厅科技攻关重点项目(222102310139) （222102310139）
河南省卫生健康委员会中医药科学研究专项课题重点课题(20-21ZY1053). （20-21ZY1053）
