中国比较医学杂志2026，Vol.36Issue(8)：97-106,10.DOI:10.3969/j.issn.1671-7856.2026.08.009
CREB介导的神经炎症在阿尔茨海默病中的研究进展
Research progress of CREB-mediated neuroinflammation in Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disease characterized by cognitive decline,with neuroinflammation being a key driver.As an important transcription factor,cyclic AMP response element binding protein(CREB)is involved in neuroinflammation,synaptic plasticity,and neuronal survival through regulation of multiple signaling pathways.This article reviews the biological functions of CREB,systematically explains the regulatory mechanisms involved in CREB-mediated signaling pathways in AD related to neuroinflammation,including cAMP/PKA,MAPK/ERK,and PI3K/AKT,and summarizes the research progress on CREB agonists of small molecule drugs,natural compounds,and cAMP analogues.Precise CREB regulation may provide a new strategy for AD treatment and provide a theoretical basis for identifying new AD therapeutic targets and drugs.This article reviews the research progress of CREB-mediated neuroinflammation in AD.关键词
阿尔茨海默病/CREB/神经炎症/信号通路Key words
Alzheimer's disease/CREB/neuroinflammation/signaling pathway分类
医药卫生引用本文复制引用
马晨菘,黄艳丽,范茗越,张振强,谢治深,李中华..CREB介导的神经炎症在阿尔茨海默病中的研究进展[J].中国比较医学杂志,2026,36(8):97-106,10.基金项目
国家自然科学基金项目(82274612) （82274612）
河南省科技研发计划联合基金(242301420019). （242301420019）
