中国比较医学杂志2026，Vol.36Issue(8)：107-118,12.DOI:10.3969/j.issn.1671-7856.2026.08.010
RhoA/ROCK通路在慢性肾脏病合并动脉粥样硬化的作用机制及中药干预研究进展
Research advances on the mechanism of RhoA/ROCK signaling in chronic kidney disease complicated with atherosclerosis and traditional Chinese medicine interventions
摘要
Abstract
Chronic kidney disease(CKD)is a globally prevalent chronic progressive disease that often coexists with atherosclerosis(AS);these conditions mutually reinforce each other,accelerating the occurrence of cardiovascular events and significantly impacting prognosis.While traditional risk factors can partly explain disease progression,CKD-specific factors such as uremic toxin accumulation,calcium-phosphorus metabolism disorders,the renin-angiotensin system,chronic inflammation,and oxidative stress also play important roles in AS progression.The RhoA/ROCK pathway plays a crucial role in pathological processes such as vascular smooth muscle cell contraction,endothelial dysfunction,inflammatory responses,and oxidative stress,making it a key molecular mechanism in CKD and AS development.As a member of the small GTPase family,RhoA can activate downstream ROCK1/ROCK2,leading to actin cytoskeletal remodeling and vascular tone regulation.In CKD,factors such as uremic toxin accumulation,elevated oxidative stress levels,and activation of the renin-angiotensin system can upregulate RhoA/ROCK signaling,further accelerating endothelial damage and AS plaque formation.Traditional Chinese medicine(TCM)and its active components have shown potential in interventional studies targeting this pathway.Various drugs,such as hirudin,hydroxy crocin,and rhodiola glycoside,can downregulate RhoA and ROCK expression or activity,improve endothelial function,and inhibit inflammation and oxidative stress,slowing the progression of CKD combined with AS.This study systematically evaluated the role of the RhoA/ROCK pathway in CKD combined with AS and the progress of TCM interventions to help reveal the molecular disease mechanisms and provide new insights and strategies for clinical prevention and treatment.关键词
慢性肾脏病/动脉粥样硬化/RhoA/ROCK通路/中药Key words
chronic kidney disease/atherosclerosis/RhoA/ROCK pathway/traditional Chinese medicine分类
医药卫生引用本文复制引用
卢姚宏,袁文萋,黄辰杰,周海东,刘庚鑫,张凤婷,晏子友,陈虞文..RhoA/ROCK通路在慢性肾脏病合并动脉粥样硬化的作用机制及中药干预研究进展[J].中国比较医学杂志,2026,36(8):107-118,12.基金项目
国家自然科学基金项目(82260908) （82260908）
2025年江西省校级大学生创新创业训练计划(S202510412127). （S202510412127）
