中国兽医杂志2026，Vol.62Issue(6)：77-84,8.DOI:10.20157/j.cnki.zgsyzz.2026.sf.011
双特异性抗体在免疫诊断和治疗中的应用
Applications of Bispecific Antibodies in Immunodiagnosis and Immunotherapy
摘要
Abstract
Bispecific antibody(BsAb),as a major breakthrough in antibody engineering,have demonstrated revolutionary potential in disease treatment in recent years.Unlike traditional monoclonal antibody(mAb),which can recognize only a single antigenic epitope,BsAb is capable of simultaneously binding to two different antigens or multiple epitopes on the same antigen.Through synergistic interactions,BsAb possess diverse biological functions,enabling more precise diagnosis and therapy.To date,various BsAb formats have been developed,each exhibiting unique structural and functional properties to address diverse practical needs.This review systematically summarizes the structural classifications of BsAb(e.g.,antibody fragment type and full-length antibody type)and construction strategies(e.g.,CrossMab,BiTE,DuoBody),with a particular focus on their applications in cancer immunotherapy,viral infections such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and influenza virus,as well as the diagnosis and treatment of animal diseases.Furthermore,the challenges faced by BsAb—such as stability,production cost,and clinical translation—are discussed,along with future development directions,including AI-assisted design,novel delivery system development,and mRNA-encoded antibody technologies.These insights provide valuable theoretical references for further research and clinical application of BsAb.关键词
双特异性抗体/结构分类/肿瘤/病毒/动物疾病Key words
bispecific antibody/structural classification/tumor/virus/animal disease分类
农业科技引用本文复制引用
邹紫阳,刘钧,潘志明,孟闯,焦新安..双特异性抗体在免疫诊断和治疗中的应用[J].中国兽医杂志,2026,62(6):77-84,8.基金项目
国家重点研发计划项目(2022YFC2604200) （2022YFC2604200）
江苏省重点研发计划(现代农业)项目(BE2021331) （现代农业）
