中国中西医结合外科杂志2026，Vol.32Issue(3)：350-354,5.DOI:10.3969/j.issn.1007-6948.2026.03.009
柴芩利胆合剂联合熊去氧胆酸对高复发风险胆总管切开取石一期缝合术后患者的疗效研究
Efficacy of Chaiqin Lidan formula combined with ursodeoxycholic acid in patients with high-risk recurrent choledocholithiasis after primary closure following choledochotomy
摘要
Abstract
Objective To investigate the clinical efficacy of Chaiqin Lidan formula combined with ursodeoxycholic acid capsules in patients at high risk of recurrence after primary closure following choledochotomy for common bile duct stones,and to explore its role in promoting postoperative recovery and reducing the risk of stone recurrence.Methods A prospective controlled study was conducted involving 120 patients with common bile duct stones at high risk of recurrence who underwent primary closure following choledochotomy in the Department of Hepatobiliary Surgery,Shanghai Municipal Hospital of Traditional Chinese Medicine,between June 2023 and June 2025.The patients were randomly assigned to a combination group and a control group,with 60 patients in each group.The control group received ursodeoxycholic acid capsules postoperatively,while the combination group was additionally treated with Chaiqin Lidan formula.Postoperative liver function indices[alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TBil)],time to improvement of clinical symptoms,incidence of postoperative complications,and stone recurrence during the follow-up period were compared between the two groups.Results On postoperative day 7,levels of ALT,AST,and TBil in the combination group were significantly lower than those in the control group(P＜0.001).The difference in the time to improvement of clinical symptoms between the two groups was not statistically significant(P＞0.05).The incidence of postoperative complications was 5.0％in the combination group,which was lower than 11.7％in the control group;however,the difference was not statistically significant(P=0.186).During the 6-month follow-up period,the stone recurrence rate was 3.3％in the combination group and 8.3％in the control group,with no statistically significant difference between the groups(P=0.436).Conclusion Chaiqin Lidan formula combined with ursodeoxycholic acid can effectively improve liver function in patients at high risk of recurrence after primary closure following choledochotomy.The combination therapy may reduce postoperative complications and short-term stone recurrence.关键词
胆总管结石/胆总管切开取石一期缝合/柴芩利胆合剂/熊去氧胆酸/复发Key words
Choledocholithiasis/primary closure after choledochotomy/Chaiqin Lidan formula/ursodeoxycholic acid/recurrence分类
医药卫生引用本文复制引用
辛海贝,白斌,苏显,周飞龙,梁晓亮,张敏峰..柴芩利胆合剂联合熊去氧胆酸对高复发风险胆总管切开取石一期缝合术后患者的疗效研究[J].中国中西医结合外科杂志,2026,32(3):350-354,5.基金项目
上海市嘉定区自然科学研究课题(JDKW-2025-0012) （JDKW-2025-0012）
