中国中西医结合外科杂志2026，Vol.32Issue(3)：361-366,6.DOI:10.3969/j.issn.1007-6948.2026.03.011
益气温阳活血方联合地舒单抗对骨质疏松性椎体压缩性骨折患者术后再骨折的疗效
Observation of Yiqi Wenyang Huoxue formula combined with denosumab in reducing postoperative re-fracture risk in patients with osteoporotic vertebral compression fracture
摘要
Abstract
Objective To investigate the effects of the Yiqi Wenyang Huoxue formula combined with denosumab on the risk of postoperative refracture,bone metabolism,and quality of life in patients with osteoporotic vertebral compression fracture(OVCF).Methods A prospective randomized controlled trial was conducted.Ninety OVCF patients were divided into a western medicine group(denosumab+Chinese medicine placebo),a Chinese medicine group(Yiqi Wenyang Huoxue formula+western medicine placebo),and a combination group(denosumab+Yiqi Wenyang Huoxue formula).All three groups underwent percutaneous vertebroplasty.After one year of treatment,clinical efficacy was assessed.Comparisons were made regarding the Visual Analog Scale(VAS)score,Osteoporosis Quality of Life Scale(OQOLS)score,bone mineral density(BMD),serum levels of osteoprotegerin(OPG),receptor activator for nuclear factor-KB ligand(RANKL),and β-CrossLaps(β-CTX).The incidence of refractures and adverse reactions was recorded.Results At 12 months postoperatively,the clinical efficacy of the combination group was superior to that of the two monotherapy groups(P＜0.05).At both 6 and 12 months postoperatively,the combination group showed significantly greater improvement in pain scores,quality of life,BMD,and bone metabolic markers compared to the monotherapy groups(P＜0.05).The incidence of refracture within one year after surgery was also lower in the combination group than in the monotherapy groups(P＜0.05).Conclusion The Yiqi Wenyang Huoxue formula combined with denosumab can effectively improve bone metabolism,reduce the risk of postoperative refracture,and enhance the quality of life in OVCF patients.The mechanism may be related to the regulation of the OPG/RANKL signaling pathway and the reduction of the bone resorption markerβ-CTX.关键词
骨质疏松性椎体压缩性骨折/益气温阳活血方/地舒单抗/骨保护素/核因子-κB受体活化因子配体/β胶原降解产物/骨代谢Key words
Osteoporotic vertebral compression fracture/Yiqi Wenyang Huoxue formula/disumab/osteoprotegerin/receptor activator of nuclear factor-kappa B ligand/β-CrossLaps/bone metabolism分类
医药卫生引用本文复制引用
余加生,秦永,冯冬前,鲍雷,张斌..益气温阳活血方联合地舒单抗对骨质疏松性椎体压缩性骨折患者术后再骨折的疗效[J].中国中西医结合外科杂志,2026,32(3):361-366,6.基金项目
江苏省中医药科技发展计划项目(MS2023158) （MS2023158）
