中国中西医结合外科杂志2026，Vol.32Issue(3)：367-372,6.DOI:10.3969/j.issn.1007-6948.2026.03.012
蠲痹方加减配合毫火针治疗膝骨性关节炎的疗效及对NLRP3/Caspase-1信号通路相关因子的影响
Efficacy of modified Juanbi formula combined with filiform fire needle therapy in treating knee osteoarthritis and its impact on factors related to the NLRP3/Caspase-1 signaling pathway
摘要
Abstract
Objective To investigate the efficacy of modified Juanbi formula combined with filiform fire needle therapy in the treatment of knee osteoarthritis(KOA)and its impact on factors related to the NOD-like receptor protein 3(NLRP3)/cysteine aspartic protease-1(Caspase-1)signaling pathway.Methods A total of 120 patients with KO A from December 2023 to March 2025 were selected and randomly assigned to 3 groups,40 cases in each group.the decoction group was treated with modified Juanbi formula,and the acupuncture group was treated with filiform fire needle therapy,the combined group was treated with modified Juanbi formula combined with filiform fire needle therapy.The efficacy,adverse reactions and quality of life were compared among the three groups,as well as the TCM syndrome scores,visual analogue scale(VAS),Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),knee joint mobility,and NLRP3/Caspase-1 signaling pathway related factors before and after treatment.Results The total effective rate of the combined group was significantly higher than that of the decoction group and the acupuncture group(P＜0.05).After treatment,compared with the decoction group and the acupuncture group,the main symptoms,secondary symptoms,total scores,VAS scores and WOMAC scores of the combined group decreased,and the knee joint activity increased(P＜0.05).After treatment,compared with the decoction group and the acupuncture group,the levels of NLRP3,Caspase-1,ASC,IL-1 β and IL-18 in the combined group decreased(P＜0.05).There were no obvious adverse reactions in the three groups.The quality of life score of the combined group was higher than that of the decoction group and the acupuncture group(P＜0.05).The differences in the aforementioned indicators between the decoction group and the acupuncture group were not statistically significant(P＞0.05).Conclusion Modified Juanbi formula combined with filiform fire needle therapy in the treatment of KOA patients can improve clinical efficacy,improve clinical symptoms,knee joint function,reduce inflammatory response,improve quality of life,and is safe and reliable,which may be related to the inhibition of NLRP3/Caspase-1 signaling pathway activation.关键词
膝骨性关节炎/蠲痹方加减/毫火针/NOD样受体蛋白3/半胱氨酸天冬氨酸蛋白酶-1/炎症反应Key words
Knee osteoarthritis/modified Juanbi formula/filiform fire needle/NOD-like receptor protein 3/cysteine aspartic protease-1/inflammatory response分类
医药卫生引用本文复制引用
付棣玮,翟宏华,尚林权,李辉,国树梅,王彪,孙国锋..蠲痹方加减配合毫火针治疗膝骨性关节炎的疗效及对NLRP3/Caspase-1信号通路相关因子的影响[J].中国中西医结合外科杂志,2026,32(3):367-372,6.基金项目
2024年度中医药类科学研究课题计划项目(2024507) （2024507）
