中国中医基础医学杂志2026，Vol.32Issue(6)：1210-1214,5.
基于"瘀热毒"理论探讨cGAS/STING 通路调控心肌梗死的机制
Exploring the Mechanism of Myocardial Infarction Regulated by the cGAS/STING Pathway Based on the"Stasis-Heat-Toxicity"Theory
摘要
Abstract
This study explores the role of the cGAS/STING pathway in the pathogenesis of myocardial Infarction(MI)based on the"stasis-heat-toxicity"theory in traditional Chinese medicine(TCM).TCM posits that"stasis-heat-toxicity"constitutes one of the key pathological factor triggering myocardial infarction.Blood stasis obstruction leads to stagnant heat transforming into toxins,with these three elements interacting through mutual promotion and transformation,thereby exacerbating disease progression.The cGAS/STING pathway plays a crucial role in the pathogenesis of myocardial infarction by modulating M1 macrophage polarization and mediating inflammatory responses.This mechanism closely aligns with the generation and dynamic transformation of stasis,heat,and toxicity,serving as their microscopic manifestation.Notably,TCM herbal interventions with heat-clearing,blood-activating,and toxin-resolving properties may attenuate inflammation by inhibiting the cGAS/STING pathway,suppress M1 macrophage polarization,improve cardiac function,and reduce Infarction size,thereby highlighting this pathway as a potential therapeutic target for MI.关键词
瘀热毒/心肌梗死/cGAS/STING 通路/免疫/炎症反应Key words
Stasis-heat-toxicity/Myocardial infarction/cGAS/STING Pathway/Immunity/Inflammatory response分类
医药卫生引用本文复制引用
陈梦婷,王栋,盛明,张鹏..基于"瘀热毒"理论探讨cGAS/STING 通路调控心肌梗死的机制[J].中国中医基础医学杂志,2026,32(6):1210-1214,5.基金项目
国家自然科学基金面上项目(82474331) （82474331）
中国博士后科学基金面上项目(2024M760286) （2024M760286）
湖北省中医药管理局中医药科研项目(ZY2025M036) （ZY2025M036）
