中国中医基础医学杂志2026，Vol.32Issue(6)：1215-1218,4.
基于"虚、郁、瘀、毒"探析老年难治性胃食管反流病的中医病机及治疗思路
Exploration of the Pathogenesis and Treatment Strategy of Elderly Refractory Gastroesophageal Reflux Disease Based on"Deficiency,Stagnation,Stasis,Toxin"
摘要
Abstract
Elderly refractory gastroesophageal reflux disease(RGERD)is a challenging disorder in gastroenterology,and treatment with acid suppression alone often yields unsatisfactory outcomes.This paper systematically elucidates the core pathogenesis of elderly RGERD as"deficiency of the middle Jiao and disorder of the pivotal mechanism".It proposes that the disease evolution follows a dynamic transformation pattern among"deficiency,stagnation,stasis,and toxin".Deficiency of the middle Jiao leads to ascending and descending derangement of Qi movement;liver Qi stagnation with phlegm obstruction generates Qi stagnation;chronic disease invading the collaterals results in simultaneous deficiency and stasis;and accumulation of turbid toxin eventually causes structural damage.Based on this pathogenetic characteristic,a five-dimensional therapeutic system is established,including reinforcing the earth and consolidating the root,dredging and rectifying Qi movement,harmonizing blood and unblocking the collaterals,resolving turbidity and detoxifying,and treating via Sanjiao differentiation.This provides a theoretical basis and clinical pathway for integrated traditional Chinese and Western medicine management of RGERD.Future research may focus on the core biological signatures of"deficiency,stagnation,stasis,and toxin"to further refine the precise application of this diagnostic and therapeutic system.关键词
难治性胃食管反流病/虚/郁/瘀/毒Key words
Refractory gastroesophageal reflux disease/Deficiency/Stagnation/Stasis/Toxin分类
医药卫生引用本文复制引用
周怡杉,刘震,肖倩文,罗楠,丁媛,王少丽..基于"虚、郁、瘀、毒"探析老年难治性胃食管反流病的中医病机及治疗思路[J].中国中医基础医学杂志,2026,32(6):1215-1218,4.基金项目
国家自然科学基金项目(82474491) （82474491）
首都卫生发展科研专项(首发 2024-2-4156) （首发 2024-2-4156）
国家卫生健康委课题(2024ZD11) （2024ZD11）
