中国卒中杂志2026，Vol.21Issue(5)：533-542,10.DOI:10.3969/j.issn.1673-5765.2026.05.003
米诺环素在急性缺血性卒中中的抗神经炎症与脑细胞保护研究进展:从机制到临床证据
Research Progress on the Anti-Neuroinflammatory Effects and Brain Cytoprotection of Minocycline in Acute Ischemic Stroke:From Mechanisms to Clinical Evidence
杨千千 1张眉扬 1陆瑶 1周东杨 1王正一蕾 1单舒乙 1刘晨辉 2王伊龙 3管玲4
作者信息
- 1. 北京 100070 首都医科大学附属北京天坛医院神经病学中心
- 2. 郑州 450052 郑州大学第一附属医院神经内科
- 3. 北京 100070 首都医科大学附属北京天坛医院神经病学中心||北京 102206 北京脑科学与类脑研究所||北京 100070 国家神经疾病医学中心||北京 100069 首都医科大学人脑保护高精尖创新中心||北京 100070 神经系统疾病国家临床医学研究中心
- 4. 北京 100070 首都医科大学附属北京天坛医院神经病学中心||北京 100081 北京理工大学前沿交叉科学院||温哥华 V6H3N1 不列颠哥伦比亚大学医学系
- 折叠
摘要
Abstract
Acute ischemic stroke is a major cause of disability and mortality.Despite continuous improvements in reperfusion therapy and secondary prevention strategies,some patients still experience varying degrees of neurological dysfunction after stroke.Neuroinflammation is involved in the onset,progression,and recovery of acute ischemic stroke and has emerged as an important therapeutic target for brain cytoprotection in recent years.Minocycline,a classic tetracycline antibiotic,exerts multiple anti-neuroinflammatory effects beyond its antimicrobial activity,including modulation of microglial activation,suppression of inflammatory cytokine release,inhibition of matrix metalloproteinase activity,and attenuation of peripheral immune-cell infiltration into the central nervous system.Preclinical studies have shown that minocycline reduces infarct volume and attenuates neurological deficits in various animal models of cerebral ischemia.Preliminary clinical studies have suggested that minocycline is generally safe and well tolerated in patients with acute ischemic stroke,although evidence for its efficacy remains inconsistent.More recently,a large-scale randomized controlled trial-EMPHASIS(efficacy and safety of minocycline in patients with moderate to severe acute ischemic stroke)trial showed that short-course minocycline treatment improves 90-day functional outcomes in patients with acute ischemic stroke,without significantly increasing safety risks.Future studies should focus on identifying the target populations most likely to benefit,optimizing the therapeutic time window,dose,and treatment duration,evaluating combination strategies with reperfusion therapy,and developing novel drug-delivery approaches as well as imaging and biomarker-based evaluation systems,thereby clarifying the clinical role and translational value of minocycline in acute ischemic stroke.关键词
急性缺血性卒中/米诺环素/神经炎症/脑细胞保护Key words
Acute ischemic stroke/Minocycline/Neuroinflammation/Brain cytoprotection分类
医药卫生引用本文复制引用
杨千千,张眉扬,陆瑶,周东杨,王正一蕾,单舒乙,刘晨辉,王伊龙,管玲..米诺环素在急性缺血性卒中中的抗神经炎症与脑细胞保护研究进展:从机制到临床证据[J].中国卒中杂志,2026,21(5):533-542,10.
