中国卒中杂志2026，Vol.21Issue(5)：561-569,9.DOI:10.3969/j.issn.1673-5765.2026.05.006
干细胞衍生物:突破活细胞治疗局限的多靶点脑细胞保护生物制品
Stem Cell Derivatives:Multi-Target Brain Cytoprotective Biological Products Beyond the Limitations of Live Cell Therapy
陈玮琪 1王伊龙 2江凌玲 1何菂 1陈彦博 3张枘南 4刘欣如 4刘文竹 4郭蕾 4王玲4
作者信息
- 1. 北京 100070 首都医科大学附属北京天坛医院神经病学中心||北京 100160 天坛-达尔文渐冻症及神经修复技术转化联合实验室
- 2. 北京 100070 首都医科大学附属北京天坛医院神经病学中心||北京 100160 天坛-达尔文渐冻症及神经修复技术转化联合实验室||北京 100070 国家神经疾病医学中心||北京 100070 神经系统疾病国家临床医学研究中心||北京 100069 首都医科大学人脑保护高精尖创新中心||北京 102206 北京脑科学与类脑研究所
- 3. 北京 100160 天坛-达尔文渐冻症及神经修复技术转化联合实验室||武汉 430074 达尔文生物科技(湖北)有限公司
- 4. 北京 100070 首都医科大学附属北京天坛医院神经病学中心
- 折叠
摘要
Abstract
For neurological deficits caused by nervous system diseases,the clinical efficacy of conventional single-target brain cytoprotective agents is limited.Although stem cell therapy holds the potential for multi-target brain cytoprotection,its clinical translation is hindered by challenges such as a low in vivo survival rate,potential to induce intracerebral inflammation,and risks of tumorigenicity.Stem cell derivatives are acellular biological products that,by enriching the paracrine active components(including stem cell secretome and extracellular vesicles),retain the pleiotropic brain cytoprotective functions of stem cells while significantly circumventing the safety and heterogeneity risks associated with live cell therapy.This article systematically reviews the mechanisms of action of stem cell derivatives and the current status of related basic and clinical research.Regarding the mechanisms of action,these derivatives can modulate the inflammatory and immune microenvironment,promote angiogenesis and neuroregeneration,and mediate intercellular substance transport,thereby establishing a new paradigm for systemic neural repair and regeneration in brain cytoprotection.Currently,stem cell derivatives have shown preliminary brain cytoprotective potential and favorable safety in research on diseases such as amyotrophic lateral sclerosis,multiple system atrophy,and ischemic stroke.Notably,in the context of increasingly stringent biomedical research and translational regulatory frameworks,as an"off-the-shelf"strategy with greater potential for standardization and industrialization,stem cell derivatives are expected to overcome the current druggability limitations in brain cytoprotection therapy and usher the field into an era of noncellular biological products.关键词
脑细胞保护/干细胞衍生物/非细胞生物制品/旁分泌效应/临床转化Key words
Brain cytoprotection/Stem cell derivative/Noncellular biological product/Paracrine effect/Clinical translation分类
医药卫生引用本文复制引用
陈玮琪,王伊龙,江凌玲,何菂,陈彦博,张枘南,刘欣如,刘文竹,郭蕾,王玲..干细胞衍生物:突破活细胞治疗局限的多靶点脑细胞保护生物制品[J].中国卒中杂志,2026,21(5):561-569,9.
