中华骨质疏松和骨矿盐疾病杂志2026，Vol.19Issue(2)：152-160,9.DOI:10.3969/j.issn.1674-2591.2026.02.001
重视骨质疏松症达标治疗的临床意义
Pay more attention on the clinical significance of treat-to-target in osteoporosis
摘要
Abstract
As the number of osteoporosis patients continues to increase,treatment strategies tend to be individu-alized and long-term management.Treat-to-target therapy is a chronic disease management strategy that sets clear treatment goals,optimizes plans,and regularly evaluates and adjusts them.This approach promotes personalized treatment and en-hances patient engagement.Treat-to-target therapy has been applied in the management of various chronic diseases.Since the concept of treat-to-target therapy for osteoporosis was proposed in 2013,its application has been limited due to the lack of unified target standards,equipment limitations,limited drug choices,and low patient compliance.In recent years,with advances in diagnostic technology and the application of new drugs,treat-to-target therapy has gradually been recognized by international authoritative organizations.Bone mineral density(BMD)T-score is recommended as the preferred quanti-tative target for treat-to-target therapy of osteoporosis.Based on the patient's baseline BMD,fracture history,and risk fac-tors,individualized post-treatment target T-scores are set.For patients with a baseline T-score≤-2.5,the recommended post-treatment target is a T-score＞-2.5;for patients with a baseline T-score≤-2.5 combined with recent fracture his-tory,recent fall history,advanced age,or poor physical function,a higher post-treatment target T-score is recommended;for patients with a baseline T-score＞-2.5 and fragility fractures,the recommended post-treatment target is to increase the T-score,with a total hip T-score increase of 0.2 and a lumbar spine T-score increase of 0.5.In terms of drug selection,therapeutic drugs should be chosen based on fracture history,BMD,and fracture site,with osteoanabolicagentsbeing the first choice for patients with extremely low BMD or recent fractures.During the treatment,BMD and bone turnover markers should be regularly monitored,patients'compliance should be assessed,and maintenance therapy or drug holidays should be considered after reaching the treatment target.For patients who have not reached the treatment target,treatment plan should be adjusted or intensified.关键词
骨质疏松症达标治疗/治疗目标/治疗方案/临床意义Key words
treat-to-target in osteoporosis/treatment goal/treatment plan/the clinical significance分类
医药卫生引用本文复制引用
王啸,徐又佳..重视骨质疏松症达标治疗的临床意义[J].中华骨质疏松和骨矿盐疾病杂志,2026,19(2):152-160,9.基金项目
国家自然科学基金(82372455) （82372455）
中核医疗"核医科技创新"计划资助项目(ZHYLZD2023001) （ZHYLZD2023001）
江苏省医学重点实验室建设项目(JSDW202254) （JSDW202254）
