中华骨质疏松和骨矿盐疾病杂志2026，Vol.19Issue(2)：183-193,11.DOI:10.3969/j.issn.1674-2591.2026.02.004
50岁以上骨质疏松性骨折患者血清尿酸与全身炎症反应指数的相关性
Correlation between serum uric acid levels and systemic inflammation response index in osteoporotic fracture patients over 50 years old
摘要
Abstract
Objective To investigate the association between serum uric acid(SUA)and the systemic inflam-mation response index(SIRI)in elderly adults with osteoporotic fracture(OPF),and to explore the modifying role of body mass index(BMI)in this relationship.Methods This cross-sectional study included 2 279 hospitalized patients aged≥50 years with primary OPF admitted to Kunshan Hospital of Jiangsu University between January 2017 and July 2022.SUA was treated as the exposure variable and SIRI as the outcome variable.Covariates included demographic fac-tors,metabolic parameters,and hematological parameters.Generalized estimating equations(GEE)and generalized addi-tive models(GAM)were used to assess linear and nonlinear associations between SUA and SIRI.Stratified analyses and two-piecewise linear regression were performed based on BMI categories.Results SUA was significantly positively associ-ated with SIRI(β=0.528,95%CI:0.294-0.761,P＜0.001).This association was strongest in the BMI 24-28 kg/m2 group,with a clear threshold effect(P=0.001).When SUA levels were below the inflection point(415 μmol/L),SUA was positively correlated with SIRI;above this threshold,the association was attenuated.Conclusion There is a BMI-de-pendent nonlinear relationship between SUA and SIRI,suggesting its potential role as an indicator of inflammation risk.关键词
骨质疏松性骨折/尿酸/全身炎症反应指数/炎症Key words
osteoporotic fracture/uric acid/systemic inflammation response index/inflammation分类
医药卫生引用本文复制引用
周晓杰,陆轲,刘周航,徐敏哲,李翀..50岁以上骨质疏松性骨折患者血清尿酸与全身炎症反应指数的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2026,19(2):183-193,11.基金项目
苏州市重大疾病多中心临床研究项目(DZXYJ202312) （DZXYJ202312）
江苏省老年健康研究项目(LKZ2022020) （LKZ2022020）
江苏省科技计划专项资金(社会发展重点研发计划)(BE2023738) （社会发展重点研发计划）
苏州医工融合协同创新研究项目(SLJ2022023) （SLJ2022023）
姑苏健康人才计划科研项目(GSWS2022105) （GSWS2022105）
