中华骨质疏松和骨矿盐疾病杂志2026，Vol.19Issue(2)：217-234,18.DOI:10.3969/j.issn.1674-2591.2026.02.008
肠道菌群、血浆蛋白与2型糖尿病性骨质疏松症:一项孟德尔随机化研究
Gut microbiota,plasma proteins,and type 2 diabetic osteoporosis:A Mendelian randomization Study
摘要
Abstract
Objective To investigate the causal relationship between gut microbiota and type 2 diabetic osteopo-rosis(T2DOP)and to evaluate the potential mediating role of plasma proteins in this association.Methods This study employed a two-sample Mendelian randomization(MR)design using summary-level data from genome-wide association studies of gut microbiota(n=8 208),plasma proteins(n=4 719),and T2DOP(1 301 cases and 38 317 controls).The inverse variance weighted(IVW)method was applied as the primary approach to estimate causal effects,comple-mented by multiple sensitivity analyses to assess the robustness and reliability of the findings and the direction of causality.Furthermore,a two-step MR analysis was conducted to evaluate the potential mediating role of plasma proteins in the rela-tionship between gut microbiota and T2DOP.Results Genetically predicted gut microbiota composition showed two posi-tive and three negative causal associations with T2DOP.In addition,21 positive and 23 negative causal associations were identified between plasma proteins and T2DOP.However,no evidence supported a mediating role of plasma proteins in the association between gut microbiota and T2DOP.Conclusion Our findings suggest that both gut microbiota and plasma proteins are causally associated with T2DOP.Nevertheless,plasma proteins do not appear to mediate the effect of gut mi-crobiota on the development of T2DOP.关键词
肠道菌群/2型糖尿病性骨质疏松症/血浆蛋白/孟德尔随机化Key words
gut microbiota/type 2 diabetic osteoporosis/plasma proteins/Mendelian randomization分类
医药卫生引用本文复制引用
陈宝瑞,武嘉鑫,雷署丰,柏林..肠道菌群、血浆蛋白与2型糖尿病性骨质疏松症:一项孟德尔随机化研究[J].中华骨质疏松和骨矿盐疾病杂志,2026,19(2):217-234,18.基金项目
国家自然科学基金面上项目(82271612) （82271612）
苏州市姑苏卫生健康领军人才计划领军人才科研项目(GSWS2022047) （GSWS2022047）
教育部老年医学与免疫学重点实验室开放课题(KJS2402) （KJS2402）
苏州大学临床医学高峰培育计划"临床医师科学家"(ML12300423) （ML12300423）
苏州大学第二附属医院学科建设助推计划"医学+X"创新团队项目(XKTJ-TD202407) （XKTJ-TD202407）
