转化医学杂志2026，Vol.15Issue(6)：901-905,5.DOI:10.3639/j.issn.2095-3097.2026.06.001
痛风性关节炎患者血清NF-κB和FGF-23表达水平及其临床意义
Expression Levels of Serum NF-κB and FGF-23 in Patients with Gouty Arthritis and Their Clinical Significance
摘要
Abstract
Objective To investigate the serum expression levels of nuclear factor-κB(NF-κB)and fibroblast growth factor 23(FGF-23)in patients with gouty arthritis(GA)and their clinical significance.Methods A total of 180 patients with GA(n=180)admitted to Beijing Friendship Hospital,Capital Medical University from June 2024 to May 2025 were selected as the GA group and were further divided into the acute phase group(n=68)and the intercritical phase group(n=112)based on disease activity.Another 189 healthy physical examinees(n=189)in the same period were selected as the control group.The serum levels of NF-κB and FGF-23 were compared among the groups.Receiver Operating Characteristic(ROC)curve was used to analyze the diagnostic value of serum NF-κB and FGF-23 levels for GA.Variables with significant differences in the univariate analysis were included in the multivariate Logistic stepwise regression analysis to explore the independent influencing factors of GA.Results The serum levels of NF-κB and FGF-23 in the GA group were higher than those in the control group(P<0.05).The serum levels of NF-κB and FGF-23 in the acute phase group were higher than those in the intercritical phase group(P<0.05).ROC curve showed that the areas under the curves for serum NF-κB,FGF-23,and their combined diagnosis of GA were 0.752,0.783,and 0.917,respectively.The AUC for combined diagnosis was superior to single diagnosis of the two indicators alone(Z=5.196,P<0.05;Z=7.034,P<0.05).The levels of serum uric acid,C-reactive protein,serum creatinine and the proportion of hypertension patients in the GA group were higher than those in the control group(P<0.05).Multivariate Logistic stepwise regression analysis showed that hypertension(OR=1.844,95%CI:1.141-2.981),serum uric acid(OR=2.232,95%CI:1.300-3.834),NF-κB(OR=2.385,95%CI:1.583-3.592),and FGF-23(OR=2.349,95%CI:1.494-3.694)were independent risk factors for GA(P<0.05).Conclusion The serum NF-κB and FGF-23 levels in GA patients are significantly elevated,and their changes are closely related to disease activity.Both indicators have favorable diagnostic value for GA,and they are also independent risk factors for the onset of GA.关键词
痛风性关节炎/核因子κB/成纤维细胞生长因子23/诊断价值Key words
gouty arthritis/nuclear factor kappa-B/fibroblast growth factor 23/diagnostic value引用本文复制引用
周航,张霞,王天琪,杨帆,刘慧兰,王磊..痛风性关节炎患者血清NF-κB和FGF-23表达水平及其临床意义[J].转化医学杂志,2026,15(6):901-905,5.基金项目
中国老年学和老年医学会科研项目(CAGG2025156) （CAGG2025156）
