转化医学杂志2026，Vol.15Issue(6)：934-939,6.DOI:10.3639/j.issn.2095-3097.2026.06.007
孕13周+6前TyG指数、Hcy、PLGF、HbA1c水平检测对妊娠期糖尿病的预测价值研究
Predictive Value of TyG Index,Hcy,PLGF and HbA1c Levels Before 13+6 Weeks of Pregnancy on Gestational Diabetes Mellitus
摘要
Abstract
Objective To analyze the predictive value of triglyceride-glucose(TyG)index,homocysteine(Hcy),placental growth factor(PLGF),and glycated hemoglobin(HbA1c)levels measured before 13+6 weeks of gestation for gestational diabetes mellitus(GDM).Methods A total of 151 pregnant women who underwent regular prenatal examinations in the First Hospital of Qinhuangdao from January 2024 to January 2025 were enrolled.According to the results of the 75 g oral glucose tolerance test(OGTT)performed at 24-28 weeks of gestation,they were divided into the GDM group(n=37)and the normal glucose tolerance(NGT)group(n=114).The OGTT results and general clinical data were compared between the two groups.Multivariate Logistic regression analysis was used to explore the influencing factors of GDM in pregnant women.Receiver operating characteristic(ROC)curves were applied to analyze the predictive value of TyG index,Hcy,PLGF,and HbA1c levels measured before 13+6 weeks of gestation for GDM.Results Fasting plasma glucose at 0 h,1 h post-load glucose,and 2 h post-load glucose in the GDM group were significantly higher than those in the NGT group(P<0.001).The proportion of family history of diabetes and levels of TyG index,Hcy,and HbA1c in the GDM group were significantly higher than those in the NGT group,while the level of PLGF was significantly lower in the GDM group than those in the NGT group(P<0.05).Multivariate Logistic regression analysis showed that PLGF was an independent protective factor for GDM in pregnant women(OR=0.715,95%CI:0.574-0.891,P=0.003),whereas TyG index,Hcy,and HbA1c were independent risk factors for GDM(OR=1.763,95%CI:1.286-2.417,P<0.001;OR=1.523,95%CI:1.204-1.927,P<0.001;OR=1.994,95%CI:1.358-2.928,P<0.001).ROC curve analysis demonstrated that the areas under the curve(AUC)of TyG index,Hcy,PLGF,and HbA1c measured before 13+6 weeks of gestation for predicting GDM alone were 0.795,0.753,0.735,and 0.740,respectively.The AUC of the combined detection of the four indicators for predicting GDM was 0.890,and the combined prediction was superior to single prediction(P<0.05).Conclusion Pregnant women with high levels of TyG index,Hcy and HbA1c and low level of PLGF before 13+6 weeks of gestation are more likely to develop GDM,and the combined detection of the above indicators has high predictive value.关键词
妊娠期糖尿病/孕早期/三酰甘油葡萄糖指数/同型半胱氨酸/胎盘生长因子/糖化血红蛋白Key words
gestational diabetes mellitus/early pregnancy/triglyceride-glucose index/homocysteine/placental growth factor/glycated hemoglobin引用本文复制引用
路春梅,裴梦然,赵云刚,齐俊巧,杨旭,魏敬艳,侯雪晶..孕13周+6前TyG指数、Hcy、PLGF、HbA1c水平检测对妊娠期糖尿病的预测价值研究[J].转化医学杂志,2026,15(6):934-939,6.基金项目
河北省2019年度医学科学研究计划项目(20191388) （20191388）
