转化医学杂志2026，Vol.15Issue(6)：940-944,5.DOI:10.3639/j.issn.2095-3097.2026.06.008
血清ST2、SIRT1、NT-proBNP水平在评估急性心肌梗死患者PCI术后并发心力衰竭风险的临床价值
Clinical Value of Serum ST2,SIRT1,and NT-proBNP Levels in Evaluating the Risk of Heart Failure After Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction
摘要
Abstract
Objective To investigate the clinical value of serum levels of growth stimulation expressed gene 2 protein(ST2),sirtuin 1(SIRT1),and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in evaluating the risk of heart failure(HF)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 195 patients with AMI who underwent PCI at the Second People's Hospital of Liaocheng from January 2023 to May 2025 were retrospectively enrolled.According to the Killip classification on the second postoperative day,they were divided into the HF group(Killip class≥Ⅱ,n=36)and the non-HF group(Killip class<Ⅱ,n=159).General clinical data were compared between the two groups.Multivariate logistic regression analysis was used to analyze the risk factors for HF in AMI patients after PCI.Receiver operating characteristic(ROC)curves were applied to evaluate the predictive value of serum ST2,SIRT1 and NT-proBNP on the day after the operation for postoperative HF in AMI patients undergoing PCI.Results There were statistically significant differences in the proportion of coronary artery lesion vessels between the two groups(P<0.05).The levels of ST2 and NT-proBNP in the HF group were significantly higher than those in the non-HF group,while the left ventricular ejection fraction and SIRT1 level were significantly lower(P<0.001).Multivariate logistic regression analysis showed that serum ST2 and NT-proBNP were independent risk factors for HF in AMI patients after PCI(OR=1.133,95%CI:1.083-1.185,P<0.001;OR=1.202,95%CI:1.105-1.308,P<0.001),whereas left ventricular ejection fraction and serum SIRT1 were independent protective factors(OR=0.717,95%CI:0.635-0.809,P<0.001;OR=0.841,95%CI:0.785-0.901,P<0.001).ROC curve analysis revealed that the area under the curve of serum SIRT1 for predicting postoperative HF in AMI patients was 0.881,which was superior to 0.860 for ST2 and 0.868 for NT-proBNP(P<0.05).Conclusion The lower the left ventricular ejection fraction and serum SIRT1 level,or the higher the serum ST2 and NT-proBNP levels on the second day after PCI,the higher the risk of HF in patients with AMI.It is recommended to pay close attention to these indicators in clinical practice and actively take measures for patients with such high-risk factors.关键词
急性心肌梗死/经皮冠状动脉介入/心力衰竭/ST2/SIRT1/NT-proBNPKey words
acute myocardial infarction/percutaneous coronary intervention/heart failure/growth stimulation expressed gene 2 protein/silent information regulator 2 related enzyme 1/N-terminal pro-B-type natriuretic peptide引用本文复制引用
常方圆,秦宪涛,许迎春,徐莎,冯泽瑞..血清ST2、SIRT1、NT-proBNP水平在评估急性心肌梗死患者PCI术后并发心力衰竭风险的临床价值[J].转化医学杂志,2026,15(6):940-944,5.基金项目
山东省医药卫生科技项目(202503010376) （202503010376）
聊城市重点研发计划政策引导类项目(2024YD44) （2024YD44）
