转化医学杂志2026，Vol.15Issue(6)：951-955,5.DOI:10.3639/j.issn.2095-3097.2026.06.010
早期肠内营养与延迟肠内营养支持对重症肺炎合并心力衰竭患者血清营养指标及预后的影响
Effects of Early Enteral Nutrition Support versus Delayed Enteral Nutrition on Serum Nutritional Markers and Prognosis in Patients with Severe Pneumonia Complicated with Heart Failure
摘要
Abstract
Objective To investigate the influence of early enteral nutrition support and delayed enteral nutrition support on serum nutritional indexes and prognosis in patients with severe pneumonia complicated with heart failure.Methods A total of 102 patients with severe pneumonia complicated with heart failure who were treated in Huai'an First People's Hospital from January 2023 to January 2025 were categorized into early group(n=52)and delayed group(n=50)according to the timing of enteral nutrition support.The early group began enteral nutrition support within 24-48 h of ICU admission,whereas the delayed group began enteral nutrition support after 48 h of ICU admission.Serum nutritional indexes[albumin(Alb),prealbumin(PAB),transferrin(TF)],inflammatory indexes[white blood cell(WBC)count,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD)]and prognosis indexes[acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score,sequential organ failure assessment(SOFA)score]before and after intervention,as well as ICU discharge rate and survival rate were compared between the two groups.Results After intervention,Alb,PAB and TF levels were increased in both groups(P<0.05),and the above levels in the early group were higher than those in the delayed group(P<0.05).The WBC,IL-6 and TNF-α levels in both groups were decreased after intervention(P<0.05),and the levels were lower in the early group than those in the delayed group(P<0.05).After intervention,LVEF was increased in the two groups(P<0.05),with the early group showing a higher LVEF than the delayed group(P<0.05).LVESD was reduced in both groups(P<0.05),with a lower LVESD in the early group(P<0.05).After intervention,both groups showed reduced APACHE Ⅱ score and SOFA score(P<0.05),with the early group exhibiting lower scores compared to the delayed group(P<0.05).The early group had higher ICU discharge rate and survival rate than the delayed group(P<0.05).Conclusion Compared with delayed enteral nutrition support,early enteral nutrition support has a better improvement effect on nutritional indexes and a more significant effect on controlling inflammation and improving cardiac function in patients with severe pneumonia complicated with heart failure,and it can achieve a better prognosis.关键词
重症肺炎/心力衰竭/肠内营养支持/营养状况/预后Key words
severe pneumonia/heart failure/enteral nutrition support/nutritional status/prognosis引用本文复制引用
蒋波,张蒙,汤慧敏,徐莉,丁艳,尹力,张东亚..早期肠内营养与延迟肠内营养支持对重症肺炎合并心力衰竭患者血清营养指标及预后的影响[J].转化医学杂志,2026,15(6):951-955,5.基金项目
江苏省卫生健康委员会医学科研面上项目(H2024155) （H2024155）
