浙江医学2026，Vol.48Issue(10)：1056-1061,6.DOI:10.12056/j.issn.1006-2785.2026.48.10.2025-761
前循环急性缺血性脑卒中患者桥接治疗后预后不良的危险因素分析
Risk factors of poor prognosis in patients with anterior circulation acute ischemic stroke after bridging therapy and establishment of a predictive model
摘要
Abstract
Objective To explore the risk factors for poor prognosis in patients with anterior circulation acute ischemic stroke(AIS)after bridging therapy.Methods A total of 104 patients with anterior circulation AIS receiving bridging therapy at Hangzhou First People's Hospital from January 2020 to October 2023 were retrospectively enrolled.The patients were divided into poor prognosis group(mRS＞2 points)and good prognosis group(mRS ≤2 points)according to the modified Rankin Scale(mRS).General clinical data,laboratory examination results and surgical related indexes associated with bridging therapy were collected in the two groups.Multivariate logistic regression analysis was used to screen the independent risk factors of poor prognosis in anterior circulation AIS patients after bridging therapy.ROC curve analysis was performed to evaluate the predictive efficiency of these independent risk factors and their combination,for poor prognosis in patients with anterior circulation AIS after bridging therapy.Results The age of patients in the poor prognosis group was higher than that in the good prognosis group;elevated fasting blood glucose level,admission National Institutes of Health Stroke Scale(NIHSS)score,the incidences of atrial fibrillation,stroke-associated pneumonia(SAP),symptomatic intracranial hemorrhage(sICH)and intracranial hemorrhage were higher in the poor prognosis group,with statistically significant differences(all P＜0.05).There were no significant differences in surgical timing and vascular recanalization grading between the two groups(all P＞0.05).SAP and admission NIHSS score were independent risk factors for poor prognosis in anterior circulation AIS patients after bridging therapy(all P＜0.05).The AUC of the combined prediction of SAP combined with admission NIHSS score for the risk of poor prognosis in patients with anterior circulation AIS after bridging therapy was higher than that of SAP or admission NIHSS score alone.Conclusion Poor prognosis of anterior circulation AIS patients after bridging therapy is correlated with SAP and admission NIHSS score,and the combination of the two indicators has high predictive value for poor prognosis in anterior circulation AIS patients after bridging therapy.关键词
急性缺血性脑卒中/前循环/桥接治疗/预后不良/静脉溶栓/血管内取栓术Key words
Acute ischemic stroke/Anterior circulation/Bridging therapy/Poor prognosis/Intravenous thrombolysis/Endovascular thrombectomy引用本文复制引用
魏婉,江翊茹,裘可凡,黄超,董晓巧,聂田,朱佳慧,何旭东,洪小琴..前循环急性缺血性脑卒中患者桥接治疗后预后不良的危险因素分析[J].浙江医学,2026,48(10):1056-1061,6.基金项目
杭州市卫生科技计划项目(A20210510) （A20210510）
