中国现代医生2026，Vol.64Issue(14)：41-46,6.DOI:10.3969/j.issn.1673-9701.2026.14.009
人脐带间充质干细胞治疗失代偿期肝硬化疗效及安全性的Meta分析
Meta-analysis on the efficacy and safety of human umbilical cord mesenchymal stem cells in treating decompensated liver cirrhosis
梁彦 1邓紫莹 1刘序友1
作者信息
- 1. 暨南大学附属广州红十字会医院消化内科,广东 广州 510220
- 折叠
摘要
Abstract
Objective To systematically assess the efficacy and safety of human umbilical cord mesenchymal stem cells(hUC-MSCs)transplantation in the management of decompensated liver cirrhosis.Methods Randomized controlled trials regarding hUC-MSCs for decompensated liver cirrhosis were electronically retrieved from databases.A total of 13 clinical studies involving 1024 patients were ultimately included.Meta-analysis were conducted on the enrolled literature.Results Meta-analysis results demonstrated that compared with control group,transplantation of hUC-MSCs improved multiple liver function parameters,ascites,and serum ammonia levels in patients with decompensated cirrhosis,but showed no significant improvement in total bilirubin levels and was associated with certain adverse reactions.Conclusion hUC-MSCs effectively improve multiple key clinical indicators in patients with decompensated cirrhosis,demonstrating clinical applicability.关键词
脐带间充质干细胞/肝硬化/失代偿期/Meta分析Key words
Umbilical cord mesenchymal stem cells/Cirrhosis/Decompensated/Meta-analysis分类
医药卫生引用本文复制引用
梁彦,邓紫莹,刘序友..人脐带间充质干细胞治疗失代偿期肝硬化疗效及安全性的Meta分析[J].中国现代医生,2026,64(14):41-46,6.
