吉林大学学报（医学版）2026，Vol.52Issue(3)：872-880,9.DOI:10.13481/j.1671-587X.20260330
肿瘤放射抗性形成机制及低剂量放射治疗协同新型增敏策略对肿瘤放射抗性抑制作用的研究进展
Research progress in formation mechanism of tumor radioresistance and inhibitory effect of low-dose radiotherapy combination with novel sensitization strategies on tumor radioresistance
摘要
Abstract
Low-dose radiotherapy(LDRT)generally refers to a radiotherapy modality with a single dose of 0.5-2.0 Gy or a total dose below 10.0 Gy.It reduces toxicity to normal tissues while retaining anti-tumor effects,and has unique biological effects such as immunomodulation,vascular normalization,and tumor microenvironment remodeling.However,tumor radioresistance severely restricts the clinical efficacy of LDRT.The development of tumor radioresistance involves multiple mechanisms,including overactivation of the DNA damage repair system,dysregulation of cell cycle checkpoints,activation of anti-apoptotic pathways,remodeling of the tumor microenvironment,imbalance of reactive oxygen species homeostasis,and epigenetic alterations.In recent years,various novel radiosensitization strategies have been developed to synergize with LDRT to inhibit radioresistance,including radiosensitization based on high-atomic-number nanomaterials,oxidative stress regulation targeting the glutathione system,metabolic reprogramming targeting key glycolytic enzymes,and immunomodulation combined with immune checkpoint inhibitors.These relevant strategies show particular application prospects in LDRT.This study elucidated the molecular mechanisms underlying tumor radioresistance,reviewed the applications and mechanisms of radiosensitization strategies,and analyzed the challenges in clinical translation from three dimensions:dose optimization,safety evaluation,and technological innovation,aiming to provide theoretical basis for the optimal design and clinical application of radiosensitization strategies.关键词
恶性肿瘤/低剂量放射治疗/放射抗性/放射治疗增敏/纳米材料/免疫治疗/协同治疗Key words
Malignant tumor/Low-dose radiotherapy/Radioresistance/Radiosensitization/Nanomaterials/Immunotherapy/Combination therapy分类
医药卫生引用本文复制引用
于洋,叶舍予,魏可新,王志成..肿瘤放射抗性形成机制及低剂量放射治疗协同新型增敏策略对肿瘤放射抗性抑制作用的研究进展[J].吉林大学学报（医学版）,2026,52(3):872-880,9.基金项目
吉林省科技厅科技发展计划项目(YDZJ202401200ZYTS) （YDZJ202401200ZYTS）
