材料工程2026，Vol.54Issue(6)：65-73,9.DOI:10.11868/j.issn.1001-4381.2024.000528
重组胶原蛋白伤口愈合水凝胶的制备及性能
Preparation and properties of recombinant collagen based wound healing hydrogels
摘要
Abstract
Recombinant collagen hydrogels are ideal materials for promoting wound healing but currently suffer from weak mechanical strength and single functionality,which limit their practical applications.A multifunctional hydrogel with a multi-network structure polymethylacrylamide-acrylic acid/tannic acid/recombinant collagen(MA-AAC/TA/COL)is prepared using in-situ polymerization.The main raw materials include recombinant collagen,tannic acid,methylacrylamide,and acrylic acid.The microstructure,mechanical properties,swelling performance,adhesive property,self-healing ability,antioxidant activity,antibacterial performance,and biocompatibility of hydrogels with different components are explored.The results show that the multi-network structure design effectively enhances the mechanical properties of the hydrogel.Its maximum tensile strain reaches(250.2±2.7)%and maximum tensile stress is(130±3)kPa.It can withstand 80%compressive deformation without breaking and the maximum compressive strength is(4.23±0.18)MPa.The hydrogel exhibits certain pH sensitivity with different swelling rates under various pH conditions.It has a maximum adhesive strength of(36.27±5.03)kPa on pig skin,a self-healing rate of 67.7%and an in-vitro antioxidant rate of(80.2±0.9)%.It shows good antibacterial effects against E.coli and S.aureus with an antibacterial rate close to 99.99%.Additionally,the hydrogel has low cytotoxicity with a cell survival rate greater than 80%.The MA-AAC/TA/COL hydrogel is expected to serve as a multifunctional wound dressing and find application in the field of wound treatment.关键词
伤口敷料/多功能水凝胶/重组胶原蛋白/自愈合/抗氧化Key words
wound dressing/multifunctional hydrogel/recombinant collagen/self-healing/anti-oxidation分类
通用工业技术引用本文复制引用
熊芳姣,景成宇,蒋玉仁,尹咏琪,陈祥雨..重组胶原蛋白伤口愈合水凝胶的制备及性能[J].材料工程,2026,54(6):65-73,9.基金项目
国家自然科学基金项目(20876180) （20876180）
