材料工程2026，Vol.54Issue(6)：74-84,11.DOI:10.11868/j.issn.1001-4381.2026.000013
导电三网络水凝胶敷料的制备及性能
Construction and performance of conductive triple-network hydrogel dressing
摘要
Abstract
Chronic wounds present significant clinical challenges due to factors such as microbial infection and an imbalanced healing microenvironment,making the healing process difficult and necessitating the development of novel dressings capable of providing both dynamic biological therapy and electrical signal modulation.However,existing hydrogel materials still face considerable difficulties in integrating multiple functionalities,including bioactivity,mechanical flexibility,conductivity,and stimuli-responsive release.To address this,this study proposes a multi-network synergistic design strategy.By combining carboxymethyl agarose(CMA),sodium alginate(SA),and polyvinyl alcohol(PVA),and incorporating multivalent ions Ca²⁺,Mg²⁺,and Zn²⁺,a triple-network hydrogel(CaPSC-MZ)with ion-conductive and pH-responsive ion-release capabilities has been successfully constructed.The results demonstrate that through the modification of agarose and the multi-network structural design,the CaPSC-MZ hydrogel exhibits an average pore size of approximately 91.47 μm,providing favorable swelling properties(50.07%)and a high water retention capacity(13.13%).The CaPSC-MZ hydrogel also demonstrates excellent foldability.Moreover,the release of Ca²⁺,Mg²⁺,and Zn²⁺ is enhanced under acidic conditions,achieving a conductivity of up to 24.81 mS/cm.Additionally,CCK-8 experiments confirm that the CaPSC-MZ hydrogel exhibits excellent biocompatibility and promotes cell proliferation.Therefore,this study provides a new material design strategy for developing smart wound dressings with integrated electrical conduction,dynamic therapeutic functionality,and mechanically adaptive properties,showing promising potential in the field of wound management.关键词
伤口敷料/多功能水凝胶/可折叠/导电水凝胶/三网络敷料Key words
wound dressing/multifunctional hydrogel/foldable/conductive hydrogel/triple-network dressing分类
通用工业技术引用本文复制引用
唐安琪,张经略,肖雨恬,张以豪,杨再伟,吴鼎宇,田军龙..导电三网络水凝胶敷料的制备及性能[J].材料工程,2026,54(6):74-84,11.基金项目
贵州省自然科学基金(黔科合基础-ZK[2024]重点021) （黔科合基础-ZK[2024]重点021）
湖南省自然科学基金(2023JJ30588) （2023JJ30588）
贵州大学智能制造与研究生联合培训基地产业与教育结合创新平台(2020-520000-83-01-324061) （2020-520000-83-01-324061）
贵州省高级创意人才培养项目([2015]4015) （[2015]4015）
贵州智能服务工程研究中心项目(2203-520102-04-04-298868) （2203-520102-04-04-298868）
