大学化学2026，Vol.41Issue(6)：64-71,8.DOI:10.12461/PKU.DXHX202508048
案例牵引,前沿融入,思维建立
Case-driven,frontier-integrated,and mindset-building:instructional design for life processes from a chemical biology perspective
摘要
Abstract
Traditional genetics,based on the central dogma,has established the fundamental framework of protein function.However,numerous complex regulatory processes in living systems cannot be fully explained by genetic sequences alone,as the central dogma has limitations in elucidating their underlying mechanisms.Chemical biology provides a transformative research paradigm by employing small molecules to directly interact with and modulate biomacromolecules,thereby decoding intricate life processes.Using Chapter 14("Chemical Regulation of Life Processes")from the"101 Plan"Chemical Biology textbook as an example,this study proposes an instructional framework structured along a spatial hierarchy from the extracellular to intracellular level("cell membrane → cytoplasm → nucleus").Through representative case studies,the framework systematically demonstrates how chemical biology deciphers complex biological processes following the logical progression of"phenomenon → mechanism → translation".Case analyses and extended discussions enable students to not only consolidate core knowledge but also develop chemical biology thinking that spans target identification,mechanistic investigation,functional modulation,and therapeutic intervention.关键词
化学"101计划"/化学生物学/教学设计Key words
Chemistry"101 Plan"/Chemical biology/Course design分类
社会科学引用本文复制引用
何薇薇,刘聪,许代超,王婧,孙敏..案例牵引,前沿融入,思维建立[J].大学化学,2026,41(6):64-71,8.基金项目
国家自然科学基金(22477026) （22477026）
