影像科学与光化学2026，Vol.44Issue(4)：30-35,68,7.DOI:10.7517/issn.1674-0475.2026.04.05
超声NT联合母体血清PTEN、galectin-3对胎儿心脏畸形的早期诊断价值
Early Diagnostic Value of Ultrasound NT Combined with Maternal Serum PTEN and Galectin-3 for Fetal Cardiac Abnormalities
摘要
Abstract
Objective:To explore the early diagnostic value of ultrasound nuchal translucency(NT)combined with maternal serum phosphatase and tensin homolog(PTEN)and galectin-3 for fetal cardiac abnormalities.Methods:A total of 112 pregnant women with suspected fetal cardiac abnormalities admitted to Jianyang People's Hospital from August 2020 to August 2023 were selected.Using pathological results of induced labor or neonatal echocardiography as the"gold standard",the subjects were divided into the malformation group(23 cases)and the normal group(89 cases).Enzyme-linked immunosorbent assay was used to detect serum markers.The diagnostic efficacy was analyzed by receiver operating characteristic curves,and DeLong test was applied to compare differences in the area under the curve(AUC).Results:Compared with the normal group,the malformation group had significantly higher NT value[(2.26±0.62)mm vs.(1.57±0.44)mm,P＜0.001]and galectin-3 level[(7.54±1.28)ng/mL vs.(5.57±1.14)ng/mL,P＜0.001],while the PTEN level was significantly lower[(11.36±2.94)ng/mL vs.(15.45±3.67)ng/mL,P＜0.001].The AUC of the combined diagnosis reached 0.945(95％CI:0.885～0.979),which was significantly superior to that of single-item detection(NT:0.807,Z=2.124,P=0.034;PTEN:0.814,Z=2.896,P=0.004;galectin-3:0.847,Z=2.313,P=0.021).The optimal cut-off value combination was NT ≥1.85 mm+PTEN≤11.63 ng/mL+galectin-3 ≥7.15 ng/mL,with a sensitivity of 95.65％and a specificity of 83.15％.Conclusion:The combination of ultrasound NT,serum PTEN and galectin-3 detection can significantly improve the early diagnostic efficacy of fetal cardiac abnormalities in the first trimester.The AUC of the combined model is 0.945,providing a high-specificity combined detection protocol for clinical screening.关键词
超声NT/PTEN/半乳糖凝集素-3/胎儿心脏畸形/早期诊断/联合诊断/ROC曲线Key words
ultrasound NT/PTEN/galectin-3/fetal cardiac abnormalities/early diagnosis/combined diagnosis/ROC curve分类
医药卫生引用本文复制引用
曾红英,颜媛,徐敏..超声NT联合母体血清PTEN、galectin-3对胎儿心脏畸形的早期诊断价值[J].影像科学与光化学,2026,44(4):30-35,68,7.基金项目
四川省科技计划项目(2021YJ0249). （2021YJ0249）
