吉林医药学院学报2026，Vol.47Issue(3)：216-219,4.
急进极高海拔环境对小鼠认知功能的损伤及防护研究
Cognitive Impairment and Protective Strategies in Mice Exposed to Rapid As-cent to Extreme High-Altitude Environments
摘要
Abstract
As human activities expand into extremely high-altitude regions,rapid exposure to the extreme high-altitude environment can trigger a cascade of complex neuropathological responses.Notably,the resultant cognitive impairment poses a significant threat to the health and safety of personnel,athletes,and travelers in these areas.Although the clinical significance of this impairment is well-established,a systematic understanding of the intricate underlying neurobiological mechanisms remains lacking.This knowledge gap has hindered the development and application of efficient and integrated protective strategies.This review synthesizes current evidence on the impact of rapid extreme high-altitude exposure on cognitive function in mice and its pathological mechanisms.Furthermore,we evaluate diverse protective approaches based on distinct defense mechanisms,aiming to provide theoretical foundations and practical insights for developing targeted intervention strategies.关键词
极高海拔/认知功能/炎症反应/防护策略Key words
extreme high altitude/cognitive function/inflammatory response/protective strategies分类
医药卫生引用本文复制引用
刘本扬,马方圆..急进极高海拔环境对小鼠认知功能的损伤及防护研究[J].吉林医药学院学报,2026,47(3):216-219,4.基金项目
吉林省教育厅科学技术研究项目(JJKH20240584KJ) （JJKH20240584KJ）
吉林医药学院博士科研启动基金项目(JYBS2021001WK) （JYBS2021001WK）
