影像科学与光化学2026，Vol.44Issue(4)：11-16,23,7.DOI:10.7517/issn.1674-0475.2026.04.02
高频超声联合单核细胞红细胞比率评估乳腺癌新辅助化疗疗效价值分析
Analysis of the Value of High-frequency Ultrasound Combined with Monocyte-erythrocyte Ratio in Evaluating the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer
摘要
Abstract
Objective:To investigate the utility of high-frequency ultrasound combined with the monocyte-to-erythrocyte ratio(MRR)in assessing the effectiveness of neoadjuvant chemotherapy(NAC)in breast cancer patients.Methods:A retrospective analysis was conducted on the data of 118 breast cancer patients who received NAC from January 2022 to December 2024.The patients were divided into the effective group(82 cases)and the ineffective group(36 cases)based on the therapeutic effect of NAC.A univariate analysis of the factors related to the efficacy of NAC was conducted;Logistic regression was used to analyze the influencing factors of the therapeutic effect of NAC;The receiver operating characteristic(ROC)curve was drawn to analyze the discriminative value of high-frequency ultrasound parameters combined with MRR for the therapeutic effect of NAC.Results:There were no differences between the two groups of patients in terms of age,body mass index(BMI),menopause,hypertension,diabetes and clinical stage(P＞0.05).Before chemotherapy,there was no difference in high-frequency ultrasound characteristic parameters and MRR levels between the two groups of patients(P＞0.05).After chemotherapy,the maximum tumor diameter,maximum tumor diameter,resistance index(RI),peak systolic velocity(PSV)and MRR in the effective group were significantly lower than those in the ineffective group(P＜0.05)[Maximum tumor diameter:(2.84±0.85)cm vs.(3.32±0.79)cm,RI:(0.41±0.12)vs.(0.62±0.14),PSV:(8.92±2.84)cm/s vs.(15.25±2.03)cm/s,MRR:(4.56±1.08)× 10-3 mmol/L vs.(6.62±1.45)× 10-3 mmol/L].The results of Logistic analysis showed that the maximum diameter of the tumor,RI,PSV and MRR were all influencing factors affecting the efficacy of NAC(P＜0.05).The efficacy of high-frequency ultrasound parameters combined with MRR in discriminating the therapeutic effect of NAC was the highest.The area under the curve(AUC)was 0.930(95％CI:0.867～0.968),and the sensitivity and specificity were 90.24％and 77.78％respectively,both of which were superior to the individual detection of each index(P＜0.05).Conclusion:High-frequency ultrasound parameters combined with MRR have good value in evaluating the efficacy of NAC in breast cancer,and its efficacy is significantly better than that of a single indicator,which can provide a reference for clinical efficacy judgment.关键词
乳腺癌/新辅助化疗/高频超声/单核细胞红细胞比率/疗效评估Key words
breast cancer/neoadjuvant chemotherapy/high-frequency ultrasound/monocyte-to-erythrocyte ratio/effect evaluation分类
医药卫生引用本文复制引用
刘璐,庞海宝,王丹丹..高频超声联合单核细胞红细胞比率评估乳腺癌新辅助化疗疗效价值分析[J].影像科学与光化学,2026,44(4):11-16,23,7.基金项目
河北省2024年度中医药类科学研究课题计划项目(2024432). （2024432）
