中国妇幼健康研究2026，Vol.37Issue(6)：1-8,8.DOI:10.3969/j.issn.1673-5293.2026.06.001
宫颈高危HPV感染与阴道病原体感染的相关性分析
Correlation analysis of cervical high-risk HPV infection and vaginal pathogen infection
沈开怡 1吴莉英 1甘宇 1杨萍兰 1曾娅 1蔡晶1
作者信息
- 1. 华中科技大学同济医学院附属协和医院妇产科,湖北 武汉 430021
- 折叠
摘要
Abstract
Objective To explore the correlation between high-risk human papilloma virus(HR-HPV)and vaginal pathogenic microorganisms(Gardnerella,Candida,Trichomonas),and to provide new ideas for the prevention and treatment of cervical cancer.Methods A retrospective analysis was conducted on the HPV typing test and vaginal pathogen test results of 6 393 women aged 25-65 years from Union Hospital,Tongji Medical College,Huazhong University of Science and Technology from January 2023 to March 2025.Chi-square test or Fisher's exact test was used for intergroup comparisons,and logistic regression analysis was performed to evaluate the association between vaginal pathogen infection and HR-HPV infection.Further,a longitudinal study design was used to assess the potential impact of vaginal pathogen outcome(persistent or clearance)on the outcome of HR-HPV infection.Results The positive rate of Gardnerella was higher in the HR-HPV positive group and the low-risk human papilloma virus(LR-HPV)positive group than in the HPV negative group(χ2=36.751,P<0.05),while there was no statistically significant difference in the positive rates of Candida and Trichomonas among the three groups(P>0.05);Univariate logistic regression analysis showed that positive detection of Gardnerella was a risk factor for HR-HPV infection(OR=1.416,95%CI:1.243-1.614,P<0.05),and there was no significant correlation between Trichomonas,Candida infection,and age factors and HR-HPV infection;Multivariate logistic regression analysis results showed that Gardnerella infection increased the risk of HR-HPV infection by 41.8%(OR=1.418,95%CI:1.243-1.616,P<0.05);A total of 339 women met the inclusion criteria for the longitudinal study,and the results showed that only in women aged 46-65,the negative rate of vaginal Gardnerella in the negative HR-HPV group was higher(PFisher=0.039).Conclusion Gardnerella may increase the risk of HR-HPV infection,and its negative conversion may promote the regression of HR-HPV.Vaginal pathogens and HR-HPV infection show a complex correlation,and large-sample multicenter studies are needed.关键词
高危型人乳头瘤病毒感染/阴道病原体/宫颈癌预防/加德纳菌Key words
high risk human papilloma virus infection/vaginal pathogen/cervical cancer prevention/Gardnerella分类
医药卫生引用本文复制引用
沈开怡,吴莉英,甘宇,杨萍兰,曾娅,蔡晶..宫颈高危HPV感染与阴道病原体感染的相关性分析[J].中国妇幼健康研究,2026,37(6):1-8,8.
