海南医科大学学报2026，Vol.32Issue(11)：862-868,7.DOI:10.13210/j.cnki.jhmu.20250910.001
刺激响应型水凝胶在心脏组织工程中的应用研究
The application study of stimulus-responsive hydrogels in cardiac tissue engineering
摘要
Abstract
Cardiac tissue engineering aims to repair or regenerate damaged myocardial tissue by constructing functional myo-cardial substitutes.However,its progress has been limited by the inability of conventional biomaterials to dynamically replicate the heart's complex mechanical and electrophysiological microenvironment.Stimuli-responsive hydrogels(SRHs),as intelligent bio-materials,present a revolutionary solution by dynamically modulating their structural and functional properties in response to exter-nal physical stimuli(e.g.,temperature,light,mechanical forces)or chemical stimuli(e.g.,pH,enzymes,ions).These materials not only demonstrate exceptional biocompatibility and tunable mechanical properties but also mimic critical cardiac dynamics,in-cluding rhythmic tissue contractions,electrical signal propagation,and pathological microenvironmental changes.Such dynamic re-sponsiveness facilitates precise regulation of cellular behaviors(e.g.,cardiomyocyte alignment,angiogenesis)and promotes target-ed tissue regeneration.This review synthesizes cutting-edge research to systematically examine the design principles and functional characteristics of various SRHs,with a particular emphasis on their multifaceted application potential in cardiac tissue engineering.By establishing fundamental theoretical frameworks and technical references,this work provides critical insights for the develop-ment of next-generation intelligent myocardial repair materials.关键词
刺激响应型水凝胶/智能材料/心脏组织工程/心肌修复Key words
Stimuli-responsive hydrogel/Smart materials/Cardiac tissue engineering/Myocardial repair分类
医药卫生引用本文复制引用
张力立,周圆缘,周燕,高亚男,胡诗雯,段成成,秦贞苗..刺激响应型水凝胶在心脏组织工程中的应用研究[J].海南医科大学学报,2026,32(11):862-868,7.基金项目
This study was supported by the National Natural Science Foundation of China(82460700) （82460700）
Hainan Provincial Natural Science Foundation of China(821RC679) 国家自然科学基金(82460700) （821RC679）
海南省自然科学基金项目(821RC679) （821RC679）
