海南医科大学学报2026，Vol.32Issue(11)：869-880,12.DOI:10.13210/j.cnki.jhmu.20251020.002
线粒体动力学在消化系统肿瘤"炎-癌"转化方面作用的研究进展
Research advances on the role of mitochondrial dynamics in the"inflammation-cancer"transition of digestive system tumours
摘要
Abstract
The"inflammation-cancer"transition denotes the biological process whereby chronic inflammatory microenviron-ments induce genomic instability,suppress immune surveillance,and activate carcinogenic signalling pathways,ultimately leading to abnormal cellular proliferation and malignant transformation.Mitochondria constitute fundamental organelles whose dynamic morphological alterations generate cellular fragments of varying lengths—a highly regulated process termed mitochondrial dynam-ics.Mitochondrial dynamics regulate cellular processes including the cell cycle,metabolism,survival,and death under both physi-ological and pathological conditions.Abnormal mitochondrial dynamics amplifies inflammatory signals,exacerbates oxidative stress,promotes cellular damage,and induces DNA mutations,being closely associated with the"inflammation-cancer"transfor-mation process in digestive system tumours.This paper systematically summarises the molecular mechanisms by which mitochon-drial dynamics facilitates"inflammation-cancer"conversion across different types of digestive system tumours.It aims to provide ex-perimental evidence and theoretical support for targeted anti-cancer therapies based on mitochondrial dynamics.关键词
线粒体动力学/"炎-癌"转化/消化系统肿瘤/肿瘤发生Key words
Mitochondrial dynamics/"Inflammation-cancer"transition/Digestive system tumors/Tumorigenesis分类
医药卫生引用本文复制引用
胡雨荷,臧云彩,谢秋利,李姗,侯青瑶,郭亚琼,孙逸龙,刘湘花,郑玉玲..线粒体动力学在消化系统肿瘤"炎-癌"转化方面作用的研究进展[J].海南医科大学学报,2026,32(11):869-880,12.基金项目
This study was supported by the National Inheritance Studio Construction Project for Distinguished Veteran Traditional Chinese Medicine Experts[No.(2022)75] （2022）
National Inheritance Studio Construction Project for Renowned Traditional Chinese Medicine Practitioners[No.(2022)245] 全国名老中医药专家传承工作室建设项目[No.国中医药人教函(2022)75号] （2022）
全国名中医传承工作室建设项目[No.国中医药人教函(2022)245号] （2022）
