摘要
Abstract
This paper aimed to construct an active monitoring model for adverse drug reactions(ADRs)of piperacillin sodium and tazobactam sodium based on the comprehensive trigger tool(GTT),and to provide reference for medical institutions to carry out active monitoring,prevention and treatment of ADRs of this drug.Referring to the trigger items recommended in the white paper of the comprehensive trigger tool,established the ADR active monitoring trigger of piperacillin sodium and tazobactam sodium by Delphi method.With the help of GTT and Chinese Hospital Pharmacovigilance System(CHPS),retrospectively analyzed the inpatient medical records of patients who used piperacillin sodium and tazobactam sodium in a hospital from March 30,2024 to September 30,2024,evaluated the performance of GTT,and statistically analyzed the occurrence of related ADRs.A total of 156 hospitalized patients were included.After manual review,there were 66 cases of adverse events caused by piperacillin sodium and tazobactam sodium,with an ADR incidence rate of 42.31%(66/156).Among them,6 cases were clinical symptom-related ADRs,accounting for 3.85%.Organ dysfunction-related ADRs were the most common,and triggers including abnormal liver function and renal function indicators were triggered 74 times,accounting for 72.55%.The voluntary reporting rate of ADRs in the same period was 6.41%(10/156).Compared with the ADRs detected by manual review,the detection rate of GTT was 660.00%of the voluntary reporting rate,with a statistically significant difference(P＜0.05).The ADR trigger and active monitoring model of piperacillin sodium and tazobactam sodium established in this paper has good feasibility,which can provide reference for the active monitoring of ADRs of this drug and other drugs.关键词
药品不良反应/全面触发工具/哌拉西林钠他唑巴坦钠/主动监测/德尔菲法/药物警戒Key words
adverse drug reactions/comprehensive trigger tool/piperacillin sodium and tazobactam sodium/active monitoring/delphi method/pharmacovigilance分类
医药卫生
