中国妇幼健康研究2026，Vol.37Issue(6)：54-64,11.DOI:10.3969/j.issn.1673-5293.2026.06.008
不同胎龄早产儿振幅整合脑电图差异及与呼吸窘迫综合征的相关性分析
Analysis of the differences in amplitude-integrated electroencephalogram among preterm infants of different gestational ages and its correlation with respiratory distress syndrome
摘要
Abstract
Objective To analyze the differences in amplitude-integrated electroencephalogram(aEEG)among preterm infants of different gestational ages and its correlation with respiratory distress syndrome(RDS).Methods A total of 102 preterm infants born in matemily and child care center of Qinhuangdao from March 2021 to March 2024 were selected as the research subjects and divided into early group(28-31+6 weeks,n=18),middle group(32-33+6 weeks,n=34),and late group(34-36+6 weeks,n=50)based on gestational age.All preterm infants were classified into RDS group(n=30)and non-RDS group(n=72)according to whether they met the diagnostic criteria for RDS.Multiple linear regression was used to analyze the correlation between gestational age and aEEG-related indicators.Logistic regression was used to analyze the association between aEEG-related indicators of preterm infants of different gestational ages and RDS.A logistic regression model combined with restricted cubic spline(RCS)was applied to analyze the dose-response relationship between aEEG-related indicators of preterm infants and the risk of RDS.Results Multiple linear regression analysis showed that gestational age was significantly positively correlated with the frequency of voltage continuity,upper and lower boundary amplitude voltages of active sleep(AS),and upper and lower boundary amplitude voltages of quiet sleep(QS)in aEEG(β ranged from 2.537 to 2.831,P<0.05),and significantly negatively correlated with sleep-wake cycle(β=-1.873,P<0.05).In different gestational ages,voltage continuity,upper and lower boundary amplitude voltages of AS,and upper and lower boundary amplitude voltages of QS were protective factors for RDS(OR ranged from 0.459 to 0.542,P<0.05),while sleep-wake cycle was a risk factor(OR ranged from 3.189 to 3.420,P<0.05).RCS analysis showed that upper and lower boundary amplitude voltages of AS and QS had a significant negative correlation trend and nonlinear dose-response relationship with RDS(overall association χ2 ranged from 22.158 to 31.849,P<0.05;nonlinear χ2 ranged from 7.580 to 8.721,P<0.05),and sleep-wake cycle had a significant positive correlation trend and nonlinear relationship with RDS(overall association χ2=18.925,P<0.05;nonlinear χ2=9.130,P<0.05).Conclusion Amplitude-integrated electroencephalogram can effectively evaluate the brain maturity of preterm infants.The background activity of electroencephalogram in preterm infants tends to mature with the increase of gestational age,and amplitude-integrated electroencephalogram is significantly correlated with the occurrence of respiratory distress syndrome in preterm infants.关键词
早产儿/振幅整合脑电图/呼吸窘迫综合征/相关性Key words
preterm infant/amplitude-integrated electroencephalogram/respiratory distress syndrome/correlation分类
医药卫生引用本文复制引用
王月怡,朱洪斌,魏雪旭,尹海伟..不同胎龄早产儿振幅整合脑电图差异及与呼吸窘迫综合征的相关性分析[J].中国妇幼健康研究,2026,37(6):54-64,11.基金项目
秦皇岛市科学技术研究与发展计划任务书(202301A246) （202301A246）
