中国妇幼健康研究2026，Vol.37Issue(6)：89-94,6.DOI:10.3969/j.issn.1673-5293.2026.06.012
乙酰半胱氨酸联合甲泼尼龙琥珀酸钠、纤维支气管镜肺泡灌洗治疗重症支原体肺炎患儿的临床研究
Clinical study on N-acetylcysteine combined with methylprednisolone sodium succinate and fiberoptic bronchoscopy with bronchoalveolar lavage for severe Mycoplasma pneumoniae pneumonia in children
摘要
Abstract
Objective To investigate the clinical efficacy of N-acetylcysteine combined with methylprednisolone sodium succinate and bronchofibroscope bronchoalveolar lavage(BAL)in children with severe Mycoplasma pneumoniae pneumonia(SMPP).Methods A retrospective analysis was conducted on the data of 106 children with SMPP from July 2022 to December 2023.Based on different treatment methods,they were grouped into control group(n=54,received methylprednisolone sodium succinate combined with BAL)and study group(n=52,adopted acetylcysteine received additional N-acetylcysteine treatment).The efficacy,symptom relief time,lung function indicators[forced vital capacity(FVC),peak expiratory flow(PEF),maximal mid-expiratory flow(MMF)],inflammatory indicators[interleukin-6(IL-6),procalcitonin(PCT),and interferon-γ(IFN-γ)],blood gas indicators[arterial partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2)],and adverse drug reaction(ADR)were compared.Results The total effective rate of the test group was higher than that of the control group,with statistically significant difference(94.23%vs.79.63%,χ2=4.927,P<0.05).The time for cough disappearance,fever reduction,sore throat disappearance,and rales disappearance in the test group was shorter than those in the control group,with statistically significant difference(t values ranged from 5.006 to 7.551,P<0.05).After treatment,the FVC,PEF,and MMF in the test group were higher than those in the control group,with statistically significant difference(t values ranged from 2.895 to 3.343,P<0.05).After treatment,the IL-6,PCT,and IFN-γ in the test group were lower than those in the control group,with statistically significant difference(t values ranged from 6.357 to 6.927,P<0.05).After treatment,the PaO2 in the test group was higher than that in the control group,while the PaCO2 was lower,with statistically significant difference(t values were 5.799 and 5.453 respectively,P<0.05).There was no significant difference in ADR incidence between the two groups(P>0.05).Conclusion N-acetylcysteine combined with methylprednisolone sodium succinate and fiberoptic bronchoscopy-assisted bronchoalveolar lavage showed good clinical efficacy in children with severe Mycoplasma pneumoniae pneumonia.It effectively improved inflammatory and blood gas indicators,significantly shortened symptom relief time,and significantly improved lung function.关键词
儿童/重症支原体肺炎/乙酰半胱氨酸/甲泼尼龙琥珀酸钠/纤维支气管镜肺泡灌洗Key words
child/severe Mycoplasma pneumoniae pneumonia/N-acetylcysteine/methylprednisolone sodium succinate/broncho-fibroscope bronchoalveolar lavage分类
医药卫生引用本文复制引用
张飞飞,代汝俊,伊文霞..乙酰半胱氨酸联合甲泼尼龙琥珀酸钠、纤维支气管镜肺泡灌洗治疗重症支原体肺炎患儿的临床研究[J].中国妇幼健康研究,2026,37(6):89-94,6.基金项目
河北省卫生健康委项目资助(20241740) （20241740）
