湖南中医药大学学报2026，Vol.46Issue(5)：1046-1053,8.DOI:10.3969/j.issn.1674-070X.2026.05.025
基于"营卫倾移"理论探讨免疫代谢紊乱在下肢动脉粥样硬化中的病机及辨治
Pathogenesis and pattern identification-based treatment of immune-metabolic dysregulation in lower extremity artery disease based on the theory of"tipping and shifting of Ying-nutrients and Wei-defence"
摘要
Abstract
Lower extremity artery disease(LEAD)is a chronic inflammatory disease characterized by atherosclerotic lesions affecting the medium and large arteries of the lower limbs.Its main clinical manifestations include numbness,cold sensation,pain,and intermittent claudication of the lower extremities;severe cases may progress to ulceration or even gangrene.The disease has a high incidence rate and tends to be protracted and difficult to cure.Based on the TCM theory of"tipping and shifting of Ying-nutrients and Wei-defence"and considering immune-metabolic dysregulation as a key pathological link,this paper proposes that the pathogenesis of LEAD evolves from the initial stage where external and internal pathogenic factors combine to cause"tipping of Ying-nutrients and Wei-defence",progresses to"shifting of Ying-nutrients and Wei-defence"with generation of phlegm and blood stasis internally,and finally leads to toxin obstructing the Ying-nutrients and Wei-defence,resulting in dysfunction of the spirit.In terms of treatment,harmonizing Ying-nutrients and Wei-defence is regarded as the general principle.At the initial stage,the priority is to tonify and harmonize Ying-nutrients and Wei-defence,dispel pathogenic factors,and prevent bi-impediment,using modified Guizhi Decoction.At the progressive stage,the focus is on resolving phlegm and removing blood stasis and reconnecting Ying-nutrients and Wei-defence,using modified Chiqilin Powder.At the advanced stage,the treatment aims to unblock the collaterals,regulate the spirit,and unblock Ying-nutrients and Wei-defence,using modified Shaoyao Gancao Decoction combined with Simiao Yong'an Decoction.This paper aims to enrich the TCM theory of"Ying-nutrients and Wei-defence"and to provide theoretical support for the clinical application of Chinese medicine in the prevention and treatment of LEAD.关键词
下肢动脉粥样硬化/营卫理论/免疫代谢/巨噬细胞Key words
lower extremity artery disease/theory of"Ying-Wei Imbalancet"/immune metabolism/macrophage分类
医药卫生引用本文复制引用
王梦雪,栾玉洁,丁炫烨,李嘉琦,张雯静,胡元会..基于"营卫倾移"理论探讨免疫代谢紊乱在下肢动脉粥样硬化中的病机及辨治[J].湖南中医药大学学报,2026,46(5):1046-1053,8.基金项目
中国中医科学院广安门医院(南区)所级科研基金课题(Y2023-21). （南区）
