实用临床医药杂志2026，Vol.30Issue(10)：38-43,6.DOI:10.7619/jcmp.20256525
血流向量成像技术联合二维斑点追踪技术评估冠心病患者增强型体外反搏治疗后左心功能早期变化的价值
Early left ventricular functional changes in coronary artery disease patients after enhanced external counterpulsation therapy via a combination assessment of vector flow mapping and 2D speckle tracking imaging
摘要
Abstract
Objective To investigate the value of vector flow mapping(VFM)combined with two-dimensional speckle tracking imaging(2D-STI)in evaluating early changes in left ventricular function indi-ces after enhanced external counterpulsation(EECP)therapy in patients with coronary artery disease(CAD).Methods A total of 84 CAD patients with normal left ventricular ejection fraction(LVEF)trea-ted in the Department of Cardiology,the Second Affiliated Hospital of Zhengzhou University,were randomly divided into EECP group(n=42)and control group(n=42).The EECP group received pharmacological therapy combined with EECP,while the control group received pharmacological therapy alone.Echocardiography was performed at admission and at 3.5 and 7 weeks of treatment to measure con-ventional cardiacfunction parameters in all subjects.VFM and 2D-STI techniques were used to ana-lyze the images,and the following parameters were measured:intraventricular pressure difference(IVPD)and pressure gradient(IVPG)during isovolumic relaxation(IR),rapid filling(RF),slow filling(SF),and atrial contraction(AC)phases,as well as global longitudinal strain(GLS)of the left ventricle.The differences and characteristics of these indices between the two groups at each time point were analyzed.Results At 3.5 weeks of treatment,the absolute values of GLS in both the EECP and control groups increased compared with those at admission,and the IVPD and IVPG during IR,RF and AC phases also increased,with statistically significant differences(P＜0.05).No significant differences were observed in the Tei index,maximal velocity(e')at the mi-tral annulus(interventricular septum and left ventricular lateral wall),E/e',left atrial volume in-dex(LAVi),peak early diastolic mitral velocity(E),peak late diastolic mitral velocity(A),E/A,or LVEF compared with those at admission(P＞0.05).At 7 weeks of treatment,the absolute val-ues of GLS,IVPD,and IVPG in both groups further increased compared with those at 3.5 weeks,while the Tei index decreased,e'increased,and E/e'decreased,with statistically significant differ-ences(P＜0.05).At 7 weeks,significant differences were observed between the two groups in IVPD-IR,IVPD-RF,IVPD-SF,IVPD-AC,IVPG-IR,IVPG-RF,IVPG-SF,IVPG-AC,GLS,Tei index,and E/e'(P＜0.05).The IVPD and IVPG during RF and AC phases were positively corre-lated with e'and GLS and negatively correlated with E/e',with more pronounced correlations ob-served compared with other periods.Conclusion VFM combined with 2D-STI can effectively evalu-ate early changes in left ventricular function after EECP therapy in patients with CAD.关键词
冠状动脉疾病/左心室功能/超声心动图/血流动力学/心肌应变/舒张期/治疗结果/随机对照试验Key words
coronary artery disease/left ventricular function/echocardiography/hemodynam-ics/myocardial strain/diastolic phase/treatment outcome/randomized controlled trial分类
医药卫生引用本文复制引用
吴安康,张晓光,秦志平,苏杭,孙雪,高新选,喻红霞..血流向量成像技术联合二维斑点追踪技术评估冠心病患者增强型体外反搏治疗后左心功能早期变化的价值[J].实用临床医药杂志,2026,30(10):38-43,6.基金项目
郑州市医疗卫生领域科技创新指导计划(2024YLZDJH095) （2024YLZDJH095）
