实用临床医药杂志2026，Vol.30Issue(8)：15-20,28,7.DOI:10.7619/jcmp.20260530
多序列MRI评估高强度聚焦超声治疗子宫肌瘤、腺肌症及剖宫产瘢痕妊娠的疗效与安全性
Efficacy and safety of high-intensity focused ultrasound in the treatment of uterine fibroids,adenomyosis and cesarean scar pregnancy using multi-sequence MRI evaluation
摘要
Abstract
Objective To investigate the efficacy and safety of multi-sequence MRI in evaluating high-intensity focused ultrasound(HIFU)treatment for uterine fibroids,adenomyosis,and cesarean scar pregnancy.Methods A total of 120 patients who underwent HIFU treatment were selected as the study subjects and divided into three groups based on disease type:uterine fibroid group(40 ca-ses),adenomyosis group(40 cases)and cesarean scar pregnancy group(40 cases).In the cesarean scar pregnancy group,some patients received combined treatment with uterine artery embolization(UAE)or methotrexate(MTX)due to richblood supply to the lesion or elevated levels of beta-human chorionic gonadotropin(β-HCG).All patients underwent multi-sequence MRI(T1WI,T2WI,DWI and dynamic contrast-enhanced MRI)within 1 week before treatment and 3 months after treatment.Changes in lesion volume and MRI signal characteristics before and after treatment were compared a-mong the three groups using a standardized evaluation system.Additionally,the incidence of adverse reactions at 24 hours,1 week and 3 months after treatment was statistically analyzed to comprehen-sively evaluate the efficacy and safety of HIFU treatment.Results At 3 months after treatment,the lesion volumes in three groups were significantly reduced compared to those before treatment(P＜0.05).Multi-sequence MRI revealed that the proportions of high T2WI signal,high DWI signal and dynamic contrast-enhanced MRI enhancement rate in the lesions of three groups were significantly decreased after treatment compared to those before treatment(P＜0.05).The incidence of adverse reactions at 24 hours,1 week and 3 months after treatment showed a gradual declining trend,with no statistically significant differences among the groups(P＞0.05).Conclusion HIFU treatment demonstrates favorable safety and efficacy in the management of uterine fibroids,adenomyosis and cesarean scar pregnancy.Multi-sequence MRI can provide imaging evidence for evaluating the effi-cacy and safety of HIFU treatment for these three diseases by quantifying lesion volume,analyzing signal characteristics,and assessing changes in blood supply.关键词
高强度聚焦超声消融术/磁共振成像/子宫肌瘤/子宫腺肌症/剖宫产瘢痕妊娠/疗效/安全性/不良反应Key words
high-intensity focused ultrasound ablation/magnetic resonance imaging/uterine fi-broids/adenomyosis/cesarean scar pregnancy/efficacy/safety/adverse reactions分类
医药卫生引用本文复制引用
王军委,孙喆..多序列MRI评估高强度聚焦超声治疗子宫肌瘤、腺肌症及剖宫产瘢痕妊娠的疗效与安全性[J].实用临床医药杂志,2026,30(8):15-20,28,7.基金项目
国家自然科学基金资助项目(82315072) （82315072）
河南省医学科技攻关计划项目(LHGJ20240970) （LHGJ20240970）
