实用临床医药杂志2026，Vol.30Issue(8)：52-56,63,6.DOI:10.7619/jcmp.20257040
血清维生素D、白蛋白水平与慢性肾脏病患者患病状态的关联性
Associations of serum vitamin D and albumin levels with disease status in patients with chronic kidney disease
摘要
Abstract
Objective To explore the association between serum 25-hydroxyvitamin D[25(OH)D],serum albumin levels,and disease status in patients with chronic kidney disease(CKD).Methods A retrospective analysis was conducted on the clinical data of 100 CKD patients(case group)and 102 healthy individuals from a health examination center during the same period(control group)collected from May 2022 to May 2025.The case group was divided into early-stage group(n=62,CKD stages 1-2)and middle-to-late-stage group(n=38,CKD stages 3-5)according to clinical staging.The levels of 25(OH)D,serum albumin,and various serum indicators were compared among the groups.Binary logistic regression analysis was used to screen for independent influencing factors related to CKD disease status;the receiver operating characteristic(ROC)curve was employed to evaluate the predictive efficacy of each indicator;and the calibration curve was used to assess the goodness-of-fit of the model.Results The levels of 25(OH)D,serum albumin level,and estimated glomerular filtra-tion rate(eGFR)in the case group were lower than those in the control group,while the levels of ser-um uric acid and the proportions of patients with a history of diabetes were higher in the case group,with statistically significant differences(P＜0.05).In the middle-to-late-stage group,the levels of 25(OH)D,serum albumin,and eGFR were lower than those in the early-stage group,and the level of serum uric acid was higher than that in the early-stage group,with statistically significant differ-ences(P＜0.05).The binary logistic regression model results showed that all three were independ-ent influencing factors for the occurrence of CKD(P＜0.05).ROC curve analysis revealed that the areas under the curve for predicting CKD disease status by 25(OH)D,serum albumin,and serum uric acid were 0.783,0.748,and 0.881,respectively.The absolute error of the calibration curve of the association model was 0.012,and the Hosmer-Lemeshow test indicated a good model fit.Conclusion Reduced serum 25(OH)D and serum albumin levels,along with elevated serum uric acid levels,are closely associated with CKD disease status and can serve as potential predictive indi-cators for CKD disease status.The association prediction model constructed in this study provides a preliminary reference for clinical-related evaluations.关键词
25-羟维生素D/血清白蛋白/高尿酸血症/肾功能不全/慢性肾脏病/病例对照研究/危险因素/Logistic模型Key words
25-hydroxyvitamin D/serum albumin/hyperuricemia/renal insufficiency/chronic kidney disease/case-control study/risk factors/logistic model分类
医药卫生引用本文复制引用
李莉,符家昌,王薇婷,王珍燕..血清维生素D、白蛋白水平与慢性肾脏病患者患病状态的关联性[J].实用临床医药杂志,2026,30(8):52-56,63,6.基金项目
国家自然科学基金(82130196) （82130196）
海南省重点研发计划项目(ZDYF2021SHF2081) （ZDYF2021SHF2081）
