江西中医药大学学报2026，Vol.38Issue(3)：58-61,67,5.DOI:10.20140/j.2095-7785.2026.03.13
温肾健脾方联合蒸脐疗法对IBS-D患者炎性因子、肠道菌群的影响
Effect of Wenshen Jianpi Formula Combined with Umbilical Steaming Therapy on Inflammatory Factors and Gut Microbiota in Patients with Diarrhea-predominant Irritable Bowel Syndrome
摘要
Abstract
Objective:To observe the clinical efficacy of Wenshen Jianpi Formula combined with umbilical steaming therapy in the treatment of patients with Diarrhea-predominant Irritable Bowel Syndrome(IBS-D)of spleen-kidney Yang deficiency syndrome,and investigate its effects on inflammatory factors and gut microbiota.Methods:A total of 80 IBS-D patients with spleen-kidney yang deficiency syndrome who met the inclusion criteria were enrolled in the outpatient and inpatient departments of The Affiliated Hospital of Jiangxi University of Chinese Medicine from January 2022 to December 2023.The patients were randomly divided into two groups,with 40 cases in the observation group and 40 cases in the control group.The observation group was treated with Wenshen Jianpi Formula combined with umbilical steaming therapy,while the control group was treated with oral Bifidobacterium Triple Viable Capsules.The treatment course for both groups was 4 weeks.After 4 weeks of treatment,the changes of total TCM syndrome score,serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),interleukin-10(IL-10)],gut microbiota,and Irritable Bowel Syndrome Quality of Life(IBS-QOL)scale score before and after treatment were compared between the two groups,and the curative effect on TCM syndromes was evaluated.Results:After treatment,the total effective rate of the observation group(95.00%)was significantly higher than that of the control group(67.50%)(P<0.05).The total TCM syndrome score,IBS-QOL score,serum levels of IL-6,IL-8 and TNF-α,as well as the counts of Enterobacter and Enterococcus in both groups were significantly decreased after treatment,and the above indicators in the observation group were lower than those in the control group(P<0.01).The serum level of IL-10 and the counts of Bifidobacterium and Lactobacillus in both groups were increased after treatment,and those in the observation group were significantly higher than the control group(P<0.01).Conclusion:Wenshen Jianpi Formula combined with umbilical steaming therapy has a significant curative effect in the treatment of IBS-D and can relieve the clinical symptoms of patients.Its mechanism of action may be related to the regulation of serum inflammatory factors and gut microbiota.关键词
蒸脐疗法/肠易激综合征/炎性因子/肠道菌群Key words
Umbilical Steaming Therapy/Irritable Bowel Syndrome/Inflammatory Factors/Gut Microbiota分类
医药卫生引用本文复制引用
王小辉,蓝阳,吴媛,葛来安..温肾健脾方联合蒸脐疗法对IBS-D患者炎性因子、肠道菌群的影响[J].江西中医药大学学报,2026,38(3):58-61,67,5.基金项目
江西省卫生健康委员会科技计划项目(202210187) （202210187）
江西省中医药管理局科技计划项目(2022B381). （2022B381）
