江西中医药大学学报2026，Vol.38Issue(3)：132-138,7.DOI:10.20140/j.2095-7785.2026.03.26
抗癌小分子前药自组装纳米制剂的研究进展
Research Progress of Self-assembled Nanopreparations for Small Molecule Prodrugs Against Cancer
摘要
Abstract
Small molecule drugs play an important role in the treatment of diseases.For many small molecule anticancer drugs,there are widespread shortcomings such as poor targeting,low solubility and poor stability,which seriously limit the clinical application of drugs.Small molecule prodrug self-assembly nanopreparations play an important role in overcoming these shortcomings of drugs.This paper summarizes the latest progress of small-molecule prodrug self-assembly nanopreparations in recent years,including the theoretical basis of self-assembly structure,classification based on prodrug structure,advantages over traditional nanoparticles,"intelligent"stimulus-response release system,multi-domain application and future challenges,etc.,aiming to provide valuable reference and enlightenment for researchers in this field.Promote the continuous innovation and development of small molecule self-assembly prodrug technology.关键词
小分子药物/自组装/靶向性/"智能"响应Key words
Small Molecule Drugs/Self-assembly/Targeting/Intelligent Response分类
医药卫生引用本文复制引用
陈后屹,黄子谦,孙勇兵..抗癌小分子前药自组装纳米制剂的研究进展[J].江西中医药大学学报,2026,38(3):132-138,7.基金项目
国家自然科学基金项目(82360705) （82360705）
江西省双千计划项目(jxSq2023201078) （jxSq2023201078）
江西省教育厅科学技术研究项目(GJJ2200911) （GJJ2200911）
江西省自然科学基金重点项目(20242BAB26174). （20242BAB26174）
