实用临床医药杂志2026，Vol.30Issue(9)：100-104,118,6.DOI:10.7619/jcmp.20260294
祛腐生肌散治疗肛瘘术后患者的临床疗效及可能机制
Clinical efficacy and possible mechanism of Qufu Shengji Powder in the treatment of patients after anal fistula surgery
摘要
Abstract
Objective To investigate the clinical efficacy of Qufu Shengji Powder in patients after anal fistula surgery and its impact on the hypoxia-inducible factor-1α(HIF-1 α)/vascular endothelial growth factor(VEGF)signaling pathway.Methods A total of 148 patients with anal fistula who un-derwent surgical treatment were selected as the study subjects.They were randomly divided into control group and observation group using a random number table method,with 74 cases in each group.The control group received conventional treatment,while the observation group received conventional treat-ment combined with Qufu Shengji Powder for a treatment course of 1 month.The wound healing status of patients in the two groups was statistically analyzed.Wound pain,granulation,and secretion scores were evaluated.Anal function,levels of inflammatory factors[interleukin-1 β(IL-1β),tumor necro-sis factor-α(TNF-α),interleukin-6(IL-6)],clinical efficacy,incidence of adverse reactions,and levels of HIF-1 α and VEGF were compared between the two groups.Results The wound healing time in the observation group was shorter than that in the control group,and the wound healing rate was higher than that in the control group,with statistically significant differences(P＜0.05).Before treat-ment,there were no statistically significant differences in wound pain,granulation and secretion scores,and levels of IL-1β,TNF-α,IL-6,HIF-1α,and VEGF between the two groups(P＞0.05).After treatment,the wound pain,granulation and secretion scores,and levels of IL-1β,TNF-α,and IL-6 in both groups were lower than those before treatment,and these values in the observation group were lower than those in the control group,with statistically significant differences(P＜0.05).Af-ter treatment,the levels of HIF-1α and VEGF in both groups were higher than those before treat-ment,and these levels in the observation group were higher than those in the control group,with statistically significant differences(P＜0.05).The effective treatment rate in the observation group was 90.54％,which was higher than the 78.38％in the control group,with a statistically signifi-cant difference(P＜0.05).There was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P＞0.05).Conclusion Qufu Shengji Powder can ef-fectively promote wound healing in patients after anal fistula surgery and has significant clinical effica-cy.Its mechanism of action may be related to the activation of the HIF-1α/VEGF signaling pathway.关键词
祛腐生肌散/肛瘘/缺氧诱导因子-1α/血管内皮生长因子/炎性因子/创面愈合/中医药疗法/不良反应Key words
Qufu Shengji Powder/anal fistula/hypoxia-inducible factor-1α/vascular endothe-lial growth factor/inflammatory factors/wound healing/traditional Chinese medicine therapy/ad-verse reactions分类
医药卫生引用本文复制引用
张静,张帅,王佳薇,李敏..祛腐生肌散治疗肛瘘术后患者的临床疗效及可能机制[J].实用临床医药杂志,2026,30(9):100-104,118,6.基金项目
四川省医药卫生科技计划项目(3128205A) （3128205A）
