实用临床医药杂志2026，Vol.30Issue(9)：129-137,9.DOI:10.7619/jcmp.20260166
昼夜节律紊乱与结直肠癌肝转移:肠道菌群-免疫轴的调控作用及研究进展
Circadian rhythm disruption and colorectal cancer liver metastasis:the regulatory role and research progress of the gut microbiota-immune axis
摘要
Abstract
Approximately 50％of patients with colorectal cancer(CRC)develop liver metastases,with circadian rhythm disruption serving as a significant risk factor;however,the synergistic regulatory mechanisms between the gut microbiota and immune microenvironment remain incompletely elucidated.In recent years,the"gut microbiota-immune axis"has provided a novel theoretical framework for dissecting this process.Circadian rhythm disruption increases the abundance of Enterobacteriaceae while decreasing that of Roseburia and Akkermansia,accompanied by aberrant accumulation of deoxycholic acid(DCA)and taurocholic acid(TCA).DC A directly suppresses the cytotoxic function of CD8+T cells via the plasma membrane Ca2+-transporting ATPase-nuclear factor of activated T cells 2(PMCA-NFAT2)pathway,whereas TCA drives the hepatic recruitment of neutrophils and myeloid-derived suppressor cells(MDSCs),which collaboratively establish an immunosuppressive pre-metastatic niche.This paper systematically reviewed the core regulatory pathways and research progress of circadian rhythm disorders driving colorec-tal cancer liver metastasis(CRLM)via the gut microbiota-immune axis.Chronotherapy,probiotic inter-ventions,and fecal microbiota transplantation(FMT)based on this axis are highlighted as promising new directions for CRLM prevention and treatment.However,discrepancies between human and murine microbiota,along with the immune heterogeneity of liver metastases,remains key bottlenecks for clinical translation.关键词
昼夜节律/结直肠肿瘤/肿瘤转移/肝肿瘤/胃肠道微生物组/免疫/菌群失调/生物钟蛋白质类Key words
circadian rhythm/colorectal neoplasms/neoplasm metastasis/liver neoplasms/gastrointestinal microbiome/immunity/dysbiosis/circadian clock proteins分类
医药卫生引用本文复制引用
卜琳雪,沈慧,聂双,吴哲洋,史晓辉,莫烽锋..昼夜节律紊乱与结直肠癌肝转移:肠道菌群-免疫轴的调控作用及研究进展[J].实用临床医药杂志,2026,30(9):129-137,9.基金项目
国家科技创新2030—"脑科学与类脑研究"重大项目(2022ZD0208100) （2022ZD0208100）
