临床神经外科杂志2026，Vol.23Issue(3)：346-351,6.DOI:10.3969/j.issn.1672-7770.2026.03.020
特发性震颤的病理生理机制及外科干预研究进展
Advances in pathophysiological mechanisms and surgical interventions for essential tremor
摘要
Abstract
Essential tremor(ET)is a movement disorder with a predominantly autosomal dominant pattern of inheritance,which is clearly defined by the 2018 International Movement Disorder Society Consensus as a"bilateral postural and/or action tremor of the upper extremities"with symptoms persisting for≥3 years,which may be accompanied by head,voice or lower limb tremor.The pathophysiologic mechanism focuses on abnormal function of the cerebello-thalamo-cortical loop,but the specific molecular pathways have not been fully elucidated.It is often differentiated from Parkinson's disease tremor,functional tremor,metabolic tremor,and pharmacological tremor.The course of ET is insidious,with mild tremor requiring no intervention in the early stages of the disease,and moderate-to-severe patients requiring pharmacological or surgical treatment.This article provides a systematic review of the neural oscillatory mechanisms of ET,genetic and environmental interactions,and evidence-based advances in new techniques for surgical intervention,with the aim of providing a comprehensive reference for clinical practice and research orientation.关键词
特发性震颤/运动障碍/病理生理机制/药物治疗/手术治疗Key words
essential tremor/movement disorders/pathophysiologic mechanisms/pharmacological treatment/surgical treatment分类
医药卫生引用本文复制引用
滕志琦,任志伟,莫咏翔,胡永生,郭松,李建宇..特发性震颤的病理生理机制及外科干预研究进展[J].临床神经外科杂志,2026,23(3):346-351,6.基金项目
北京市属医院科研培育计划项目(PX2022034) （PX2022034）
