军事医学2026，Vol.50Issue(5)：374-380,7.DOI:10.7644/j.issn.1674-9960.2025-00253
脑类器官在神经发育及相关疾病中的研究进展
Research progress in brain organoids in neural development and related diseases
摘要
Abstract
Brain organoids are three-dimensional in vitro models that mimic the structure and function of human neural tissue.Current methodologies involve whole-brain organoids and region-specific organoids,with emerging protocols for vascularization,immunocompetence,and multi-organ integration.As an innovative technological platform bridging basic research and clinical applications,brain organoids promise broad prospects in organ development modeling,elucidation of disease mechanisms,drug screening,and regenerative medicine,having become a vital tool for studying neurodevelop-mental and neurodegenerative disorders.However,such challenges persist as limited structural complexity,incomplete functional maturation,and asynchronous development,which constrain their ability to fully recapitulate the human brain.This review summarizes recent advances in research on brain organoids,highlighting their potential in studying the development of the nervous system and associated disorders.Problems that remain to be solved are also outlined in order to provide data and references for future research in this field.关键词
脑类器官/神经发育/神经发育性疾病/疾病模型Key words
brain organoids/neurodevelopment/neurodevelopmental disorders/disease modeling分类
医药卫生引用本文复制引用
杨睿,姜慧慧,吴海涛..脑类器官在神经发育及相关疾病中的研究进展[J].军事医学,2026,50(5):374-380,7.基金项目
国家杰出青年科学基金项目(32325025) （32325025）
