军事医学2026，Vol.50Issue(5)：381-385,5.DOI:10.7644/j.issn.1674-9960.2025-00211
恐惧记忆的分子印迹:双链DNA损伤在创伤后应激障碍中的潜在机制探讨
Molecular imprinting of fear memory:mechanisms and therapeutic prospects of DNA damage in post-traumatic stress disorder
付文亮 1高波 1张超1
作者信息
- 1. 军事科学院军事医学研究院,北京 100850
- 折叠
摘要
Abstract
Post-traumatic stress disorder(PTSD)is a chronic anxiety disorder that occurs after an individual experienc-es a major traumatic event,characterized by the overgeneralization of fear memory,spontaneous retrieval,and impaired extinction.Recent studies have revealed that neuronal activity-induced DNA damage is not only involved in the formation and consolidation of fear memory,but also closely associated with the pathological mechanisms of PTSD due to abnormalities in its repair pathways.This review summarizes the physiological sources,molecular mechanisms,and physiological significance of neuronal DNA damage in general and the potential regulatory role of DNA double-strand breaks(DSBs)in the formation and maintenance of fear memory in particular.It also explores the underlying mechanisms by which DSBs may serve as molecular imprints of fear memory.This review also predicts the translational potential of targeting DNA damage repair pathways in PTSD treatment in the hope of providing data for developing novel therapeutic drugs for PTSD.关键词
DNA损伤/恐惧记忆/创伤后应激障碍/DNA修复Key words
DNA damage/fear memory/post-traumatic stress disorder/DNA repair分类
生物科学引用本文复制引用
付文亮,高波,张超..恐惧记忆的分子印迹:双链DNA损伤在创伤后应激障碍中的潜在机制探讨[J].军事医学,2026,50(5):381-385,5.
