军事医学2026，Vol.50Issue(5)：392-400,9.DOI:10.7644/j.issn.1674-9960.2025-00273
程序性细胞死亡驱动心血管疾病机制研究进展
Advances in the mechanism of programmed cell death driving cardiovascular disease
摘要
Abstract
The pathogenesis of cardiovascular diseases is complex,and myocardial cell death is a leading factor behind disease progression and adverse outcomes.Programmed cell death(PCD),the primary execution form of myocardial cell death,has such key subtypes as ferroptosis,apoptosis,necroptosis,autophagy,and pyroptosis.In recent years,the regulatory mechanisms and pathophysiological roles of various PCD subtypes in cardiovascular diseases have been gradually clarified,opening up new spheres and providing potential targets for the targeted therapy of these diseases.This review summarizes the key molecular mechanisms and crosstalk regulatory relationships of different PCD subtypes in cardiovascular diseases,and analyzes the synergistic and antagonistic effects among various pathways in the hope of providing data for the precise diagnosis and optimization of therapeutic regimens for cardiovascular diseases.关键词
心血管疾病/程序性细胞死亡/铁死亡/凋亡/坏死性凋亡/自噬/焦亡Key words
cardiovascular diseases/programmed cell death/ferroptosis/apoptosis/necroptosis/autophagy/pyroptosis分类
医药卫生引用本文复制引用
何雨若,李晓莉,候文杰,牛晓琳..程序性细胞死亡驱动心血管疾病机制研究进展[J].军事医学,2026,50(5):392-400,9.基金项目
国家自然科学基金面上项目(82370251) （82370251）
